Posthemorrhagic ventricular dilation is a common clinical problem in preterm infants who have incurred an intraventricular hemorrhage. Presently there are no clinically applicable methods to follow quantitatively the progression of ventricular dilation at bedside. We describe the in vivo validation of a method to measure ventricular volume using bedside real-time cranial ultrasonography. Six infants undergoing either serial lumbar punctures or cerebral ventricular reservoir taps for posthemorrhagic hydrocephalus were studied. The cerebrospinal fluid (CSF) volume removed ranged from 5.5 mL to 30 mL. A strong correlation was found (r2 = 0.84) between the volume of CSF removed by reservoir tap and the change in ventricular volume calculated by the ultrasound method, whereas the correlation between the volume of CSF removed at lumbar puncture and the change in ventricular volume calculated by the ultrasound method was not as strong (r2 = 0.70). Limitations and sources of error in the method are discussed. We conclude that this procedure is accurate and offers a quantitative method to follow longitudinally posthemorrhagic progressive ventricular dilation.
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http://dx.doi.org/10.7863/jum.1990.9.1.9 | DOI Listing |
Alzheimers Dement
December 2024
National Center for Neurological Disorders, Shanghai, Shanghai, China.
Background: The heart-brain connection has been proposed to correlate cardiac disorders with brain health. However, the associations between subclinical alterations in cardiac structure or function and Alzheimer's disease (AD) pathologies haven't been fully elucidated. This study aimed to delineate the interrelationships between the subclinical alterations in the left heart, cerebrospinal fluid (CSF) AD biomarkers, and cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Olfactory deficits are predictive of cognitive decline and dementia. Previous studies have linked brain magnetic resonance imaging markers of neurodegeneration to olfactory deficits in aging; however, these studies analyzed cross-sectional data for markers, olfaction, or both. Furthermore, potential cerebrovascular contributions to understanding why olfactory deficits predict dementia remain unexplored.
View Article and Find Full Text PDFAnn Neurol
January 2025
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany.
Objective: Despite the overwhelming evidence for profound and longstanding effects of early-life stress (ELS) on inflammation, brain structure, and molecular aging, its impact on human brain aging and risk for neurodegenerative disease is poorly understood. We examined the impact of ELS severity in interaction with age on blood-based markers of neuroinflammation and neurodegeneration, brain volumes, and cognitive function in middle-aged women.
Methods: We recruited 179 women (aged 30-60 years) with and without ELS exposure before the onset of puberty.
Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: Amyloid-β (Aβ) plaques and tau pathogenesis in the brain precede cognitive decline in the progression of Alzheimer's dementia, yet the extent to which these measures can predict localized brain tissue atrophy has not been studied in a large, diverse population. Multisite studies offer robust statistical power with larger sample sizes but are confounded by variations in biomarker quantification across studies, including variations in MRI scanners, PET tracers, and CSF assays. Longitudinal data from N=1223 individuals from four independent AD studies were harmonized to assess localized brain tissue atrophy over 2 to 5 years.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) progression is often characterized by the accumulation of amyloid and tau proteins, which can be linked to impaired brain clearance mechanisms, including the glymphatic system. Our research evaluates noninvasive MRI-based indicators of brain clearance functionality, such as choroid plexus volume (CPV), lateral ventricular volume (LVV), and the perivascular space diffusivity index (ALPS index), throughout various stages of AD.
Method: We analyzed MRI data measuring CPV, LVV, and ALPS index from participants categorized as amyloid-beta (Aβ)- negative healthy controls (HC), Aβ-positive HC, Aβ-negative subjective cognitive decline (SCD), Aβ-positive SCD, mild cognitive impairment (MCI), and AD, using the Alzheimer's Disease Neuroimaging Initiative database.
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