Hoover and Duckett identified the relationship between valves, reflux, and dysplasia, commonly known as VURD (Posterior urethral valve, Unilateral vesicoureteral reflux, Renal dysplasia) syndrome. They noted preserved contralateral renal function in patients with unilateral reflux into a non-refluxing kidney. The proposed mechanism of this protection is that the refluxing collecting system acts as a pressure pop-off. Here we report three cases of VURD syndrome.
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Posterior Urethral Valves, Unilateral Vesicoureteral Reflux, and Renal Dysplasia (VURD) Syndrome: Long-Term Longitudinal Evaluation of the Kidney Function.
Int J Environ Res Public Health
June 2023
Pediatric Nephro-Urology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London SE1 7EH, UK.
The presence of unilateral vesicoureteral reflux (VUR), and renal dysplasia associated with posterior urethral valves (PUV) (VURD syndrome) was believed to represent a pressure-released pop-off mechanism protecting kidney function. We aimed to investigate its role with respect to long-term kidney function in a cross-sectional and longitudinal analysis. We compared the iohexol glomerular filtration rate (GFR) measured at 5 (GFR) and 10 (GFR) years of age in children with (Group A) and without (Group B) VURD syndrome, who underwent PUV resection under 2 years of age.
View Article and Find Full Text PDFPosterior urethral valves, pressure pop-offs, and kidney function: systematic review and meta-analysis.
World J Urol
July 2023
Division of Urology, Department of Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Purpose: To determine the role of pressure pop-off mechanisms, including vesicoureteral reflux and renal dysplasia (VURD) syndrome, in determining long-term kidney outcomes in boys with posterior urethral valves (PUV).
Methods: A systematic search was performed in December 2022. Descriptive and comparative studies with a defined pressure pop-off group were included.
Does VURD syndrome impact voiding efficiency in posterior urethral valves?
J Pediatr Urol
August 2023
Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:
Introduction: There is debate regarding the effect of VURD syndrome, consisting of vesicoureteral reflux (VUR) and ipsilateral kidney dysplasia, on long-term outcomes in boys with posterior urethral valve (PUV). Here, we assessed whether VURD syndrome played a "protective" role on long-term bladder outcomes and voiding efficiency in boys with PUV.
Materials And Method: A retrospective chart review was conducted for toilet-trained children with PUV managed at our institution between 2000 and 2022, only excluding cases without recorded uroflowmetry studies.
VURD syndrome in an infant presenting with potentially fatal staphylococcal urinary tract infection and septicaemia.
BMJ Case Rep
November 2016
Centro Materno Infantil Do Norte, Centro Hospitalar do Porto, Porto, Portugal.
VURD syndrome--does it really preserve long-term renal function?
J Urol
May 2014
Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
Purpose: VURD (posterior urethral valves, unilateral vesicoureteral reflux and renal dysplasia) syndrome is the combination of persistent unilateral vesicoureteral reflux associated with an ipsilateral dysplastic, poorly functioning kidney in patients with posterior urethral valves. It was postulated that this syndrome may result in preservation of long-term renal function due to a pressure release pop-off mechanism. We determined the effects of VURD long-term renal outcomes.
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