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A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy.
Drug Deliv
December 2025
University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary.
Drug-loaded liposomes incorporated in nanofibrous scaffolds is a promising approach as a multi-unit nanoscale system, which combines the merits of both liposomes and nanofibers (NFs), eliminating the drawback of liposomes' poor stability on the one hand and offering a higher potential of controlled drug release and enhanced therapeutic efficacy on the other hand. The current systematic review, which underwent a rigorous search process in PubMed, Web of Science, Scopus, Embase, and Central (Cochrane) employing (Liposome AND nanofib* AND electrosp*) as search keywords, aims to present the recent studies on using this synergic system for different therapeutic applications. The search was restricted to original, peer-reviewed studies published in English between 2014 and 2024.
View Article and Find Full Text PDFRole of pH in Modulating RNA-Protein Interactions in TRBP2-dsRBD2: An Interplay between Conformational Dynamics and Electrostatic Interactions.
J Phys Chem B
December 2024
Department of Chemistry, Indian Institute of Science Education and Research, Dr. Homi Bhabha Road, Pune 411008, India.
Understanding RNA-protein interactions is crucial for uncovering the mechanisms of cellular processes and can provide insights into the basis of various diseases, paving the way for the development of targeted therapeutic interventions. Exposure to stress conditions, such as hypoxia, leads to a drop in intracellular pH, which, in turn, alters the ionization states of amino acid residues and RNA bases, affecting the charge distribution and electrostatic interactions between RNA and proteins. In addition, pH also perturbs the structure and dynamics of proteins via the disruption of H-bonds and ionic interactions.
View Article and Find Full Text PDFMerging and Clipping Nets for the Synthesis of Three- and Two-Merged Net Metal-Organic Frameworks.
J Am Chem Soc
December 2024
Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, and Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, Barcelona 08193, Spain.
Herein, we report how merging and clipping nets in metal-organic frameworks (MOFs) can be controlled in a single-crystal-to-single-crystal fashion using three different approaches─the merged net, clip-off chemistry, and linker reinstallation─to design and synthesize three- and two-merged net MOFs. Initially, we show the formation of three isoreticular three-merged net MOFs by linking a trimeric Sc cluster, Sc(μ-Ο)(-COO), with ditopic zigzag and tritopic linkers. The resulting MOFs exhibit three-merged edge-transitive nets─ + + ─for the first time.
View Article and Find Full Text PDFDiverse Synthesis of Arene-Fused [n.1.1]-Bridged Molecules via Catalytic Cycloaddition and Rearrangement Reactions.
Angew Chem Int Ed Engl
December 2024
Xi'an Jiaotong University, Frontier Institute of Science and Technology, 99 Yanxiang road, Yanta district, 710054, Xi'an, CHINA.
Although great advancement has been made in synthesis of 3D bridged bicyclic[n.1.1]-bioisosteres, facile construction of 2D/3D merged molecules incorporating bridged rings, as novel chemical space in drug discovery, remains a significant challenge.
View Article and Find Full Text PDFNMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes.
Cell Biol Toxicol
December 2024
Department of Obsterics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.
Background: Globally, pre-eclampsia (PE) poses a major threat to the health and survival of pregnant women and fetuses, contributing significantly to morbidity and mortality. Recent studies suggest a pathological link between PE and ferroptosis. We aim to utilize non-negative matrix factorization (NMF) clustering and machine learning algorithms to pinpoint disease-specific genes related to the process of ferroptosis in PE and investigate likely underlying biochemistry mechanisms.
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