AI Article Synopsis
- Three new diterpenes and two new neolignans were discovered from the fruits of Vitex rotundifolia, along with nineteen known compounds.
- The structures of these compounds were determined using techniques like NMR and mass spectrometry.
- Several isolated compounds showed the ability to inhibit nitric oxide production in RAW264.7 cells, with IC50 values between 11.3 to 24.5μM.
Article Abstract
Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5μM.
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| http://dx.doi.org/10.1016/j.bmcl.2013.08.004 | DOI Listing |
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