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| http://dx.doi.org/10.1111/jch.12154 | DOI Listing |
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Successful Surgical Management of Grade 4 Gynecomastia in a Renal Transplant Recipient.
Plast Reconstr Surg Glob Open
November 2024
From the Department of Surgery, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia.
This case report details the clinical presentation, surgical intervention, and postoperative management of a 36-year-old male renal transplant recipient with grade 4 gynecomastia, classified by the Rohrich scale. The patient had hypertension and was on nifedipine, metoprolol, allopurinol, prednisol, tacrolimus, and mycophenolate. With a body mass index of 31 kg/m and significant breast hypertrophy 4 months posttransplant, surgical intervention was chosen.
View Article and Find Full Text PDFThe Impact of Uric Acid-Lowering Therapy on the Progression of Non-dialysis Chronic Kidney Disease: A Prospective Cohort Study.
Cureus
September 2024
Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, VNM.
Article Synopsis
- This study examines how lowering uric acid levels can impact the progression of chronic kidney disease (CKD) over three months in patients not on dialysis.
- Researchers conducted a study with 126 CKD patients, finding a high prevalence of hyperuricemia and identifying factors like diet and BMI that influence uric acid levels.
- Results showed that a combination of diet changes and uric acid-lowering medication significantly improved kidney function, with nearly half of the patients reaching target uric acid levels in three months.
Diagnostic Complexities and Management of Gouty Arthritis With Suspected Seronegative Rheumatoid Arthritis and Malignancy in an Elderly Male.
Cureus
September 2024
General Surgery, North Cumbria Integrated Care NHS Foundation Trust, Carlisle, GBR.
Article Synopsis
- Rheumatoid arthritis (RA) and gout are different types of inflammatory arthritis; RA involves autoimmune issues while gout is caused by urate crystal deposits, making diagnosis challenging, especially in older patients.
- A 77-year-old man with chronic gout and various health issues presented with knee pain, raising suspicion for RA despite negative serological tests, leading to imaging that indicated chronic gouty tophi.
- Effective management requires distinguishing between RA and gout, using imaging techniques for accurate diagnosis, and addressing the complexities of treating elderly patients with multiple comorbidities potentially at risk for malignancy.
Allopurinol, Febuxostat, and Nonuse of Xanthine Oxidoreductase Inhibitor Treatment in Patients Receiving Hemodialysis: A Longitudinal Analysis.
Kidney Med
November 2024
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Rationale & Objective: Allopurinol and febuxostat, which are xanthine oxidoreductase inhibitors, have been widely used as uric acid-lowering medications. However, evidence regarding their cardiovascular effects in hemodialysis is insufficient. This study compared the effects of allopurinol and febuxostat on mortality and cardiovascular outcomes in patients receiving hemodialysis.
View Article and Find Full Text PDFDiuretic and Anti-hyperuricemic Effects of Geranyl Acetate in Rats.
Curr Med Chem
September 2024
Laboratory of Cardiometabolic Pharmacology, Federal University of Paraná, Curitiba, Brazil and Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil.
Background: Geranyl acetate, a compound found in plant oils, has been studied for its potential effects on renal and cardiovascular ailments.
Objective: This study aimed to investigate the diuretic and anti-hyperuricemic properties of geranyl acetate in male Wistar rats using a hyperuricemia-induced rat model.
Methods: Molecular docking studies were conducted to assess geranyl acetate's interactions with various targets.
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