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| http://dx.doi.org/10.1111/irv.12081 | DOI Listing |
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Enhancing antibody levels and T cell activity of quadrivalent influenza vaccine by combining it with CpG HP021.
Sci Rep
December 2024
State Key Laboratory for Diagnosis, Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
Influenza virus infections are a serious danger to people's health worldwide as they are responsible for seasonal flu outbreaks. There is an urgent need to improve the effectiveness and durability longevity of the immune response to influenza vaccines. We synthesized the CpG HP021 and examined the impact of it on the immune response to an influenza vaccine.
View Article and Find Full Text PDFLarvae Meal Enhances Immune Response by Improving Serum Immunoglobulin, Intestinal Barrier and Gut Microbiota of Sichuan White Geese After Avian Influenza Vaccination.
Vet Sci
December 2024
Department of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Larvae Meal (HILM) has been observed to enhance growth performance and immune function, yet the effects and mechanisms in geese remain less understood. Experiment I included 64 Sichuan White Geese to investigate the optimal additive amount of HILM in diet, and experiment II included 32 Sichuan White Geese to access serum immunoglobulin, spleen immune-related genes, intestinal morphology and gut microbiota at the optimal additive amount of HILM. The results showed that the addition of 1% HILM significantly increased the ADG of Sichuan White Geese ( < 0.
View Article and Find Full Text PDFRoute Optimization for UVC Disinfection Robot Using Bio-Inspired Metaheuristic Techniques.
Biomimetics (Basel)
December 2024
Institute of Knowledge Technology, University Complutense of Madrid, 28040 Madrid, Spain.
The COVID-19 pandemic highlighted the urgent need for effective surface disinfection solutions, which has led to the use of mobile robots equipped with ultraviolet (UVC) lamps as a promising technology. This study aims to optimize the navigation of differential mobile robots equipped with UVC lamps to ensure maximum efficiency in disinfecting complex environments. Bio-inspired metaheuristic algorithms such as the gazelle optimization algorithm, whale optimization algorithm, bat optimization algorithm, and particle swarm optimization are applied.
View Article and Find Full Text PDFLipid nanoparticles encapsulating both adjuvant and antigen mRNA improve influenza immune cross-protection in mice.
Biomaterials
December 2024
Center for Inflammation, Immunity & Infection, Institute for Biomedical Science, Georgia State University, Atlanta, GA, USA. Electronic address:
The rapid approval of SARS-CoV-2 mRNA lipid nanoparticle (LNP) vaccines indicates the versatility of mRNA LNPs in an urgent vaccine need. However, the mRNA vaccines do not induce mucosal cellular responses or broad protection against recent variants. To improve cross-protection of mRNA vaccines, here we engineered a pioneered mRNA LNP encapsulating with mRNA constructs encoding cytokine adjuvant and influenza A hemagglutinin (HA) antigen for intradermal vaccination.
View Article and Find Full Text PDFDual-Engineered Phage Vaccine Platform Facilitates STING Activation for Influenza Protection.
ACS Appl Mater Interfaces
December 2024
Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362400, China.
Influenza epidemics remain a global public health challenge. Vaccination with nucleic acid-based vaccines, which trigger strong cellular and humoral immune responses, represents a promising approach for preventing virus infection. However, its effectiveness relies on efficient delivery and an immunoadjuvant.
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