AI Article Synopsis
- - Recent findings emphasize that issues with protein folding and degradation are crucial in the development of lung diseases and complications.
- - The National Heart, Lung, and Blood Institute held a workshop to explore how these findings in proteostasis can enhance our understanding of lung disease and lead to better diagnostics and treatments.
- - The workshop aimed to pinpoint knowledge gaps in proteostasis related to lung disease, discuss new research advancements, and showcase innovative technologies that could be used therapeutically.
Article Abstract
Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919126 | PMC |
| http://dx.doi.org/10.1164/rccm.201306-1164WS | DOI Listing |
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