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Unexplained infertility and age-related infertility: indistinguishable diagnostic entities but different IVF prognosis.
Hum Reprod
September 2024
Maternal and Child Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, ART Unit, Milan, Italy.
Study Question: Is IVF indicated for couples with age-related infertility?
Summary Answer: IVF may be of doubtful utility for age-related infertility.
What Is Known Already: A diagnosis of unexplained infertility is drawn when the diagnostic work-up fails to identify any patent cause. Although typically managed uniformly, unexplained infertility is likely to comprise a wide range of conditions, including age-related infertility (at least in older women).
Designing SERS nanotags for profiling overexpressed surface markers on single cancer cells: A review.
Talanta
August 2024
Mass Spectrometry Laboratory, MolSys Research Unit, University of Liège, Belgium.
This review focuses on the chemical design and the use of Surface-Enhanced Raman Scattering (SERS)-active nanotags for measuring surface markers that can be overexpressed at the surface of single cancer cells. Indeed, providing analytical tools with true single-cell measurements capabilities is capital, especially since cancer research is increasingly leaning toward single-cell analysis, either to guide treatment decisions or to understand complex tumor behaviour including the single-cell heterogeneity and the appearance of treatment resistance. Over the past two decades, SERS nanotags have triggered significant interest in the scientific community owing their advantages over fluorescent tags, mainly because SERS nanotags resist photobleaching and exhibit sharper signal bands, which reduces possible spectral overlap and enables the discrimination between the SERS signals and the autofluorescence background from the sample itself.
View Article and Find Full Text PDFHIV epidemiology, prevention, treatment, and implementation strategies for public health.
Lancet
February 2024
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
The global HIV response has made tremendous progress but is entering a new phase with additional challenges. Scientific innovations have led to multiple safe, effective, and durable options for treatment and prevention, and long-acting formulations for 2-monthly and 6-monthly dosing are becoming available with even longer dosing intervals possible on the horizon. The scientific agenda for HIV cure and remission strategies is moving forward but faces uncertain thresholds for success and acceptability.
View Article and Find Full Text PDF[Twelve tips for a good medical consultation in primary care.].
Recenti Prog Med
December 2023
Department of General Practice, University Hospital Würzburg, Germany.
Article Synopsis
- - The recent pandemic highlights the need for a shift in primary care, moving away from hyper-specialization towards a more holistic approach that recognizes the complexities of patient care and the competencies required by physicians.
- - This narrative review aims to provide primary care physicians with essential tips for effective medical consultations, focusing on competencies redefined within the context of managing complex care.
- - Key concepts for these tips include understanding patient subjectivity, employing clinical reasoning methods, contextualizing working diagnoses, analyzing evolving scenarios, managing uncertainty, and emphasizing patient involvement and communication.
Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan.
EJNMMI Phys
October 2023
Department of Radiology and Nuclear Medicine, Amsterdam, University Medical Centers, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Background: Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the performance of a framework for the harmonization of brain PET scans in a multi-center European clinical trial.
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