AI Article Synopsis
- * The first layer is a specialized copolymer, followed by six layers of poly(L-lysine) and poly(methacrylic acid), with monitoring techniques including microelectrophoresis and X-ray scattering to assess the polymer buildup.
- * The modified cubosomes aim to minimize the rapid release of drugs and were tested successfully with fluorescein, a model hydrophilic small molecule, showcasing their potential for improved drug delivery systems.
Article Abstract
Cubic phase lyotropic liquid crystalline colloidal dispersions (cubosomes) were surface-modified with seven polyelectrolyte layers using a layer-by-layer (LbL) approach. The first layer consisted of a copolymer synthesized from methacrylic acid and oleoyl methacrylate for enhanced incorporation within the bilayer of the cubic nanostructure. Six additional layers of poly(L-lysine) and poly(methacrylic acid) were then sequentially added, followed by a washing procedure to remove polymer aggregates from the soft matter particles. Polymer buildup was monitored via microelectrophoresis, dynamic light scattering, and small-angle X-ray scattering. Polymer-coated cubosomes were observed with cryo-transmission electron microscopy. A potential application of the modified nanostructured particles presented in this study is to reduce the burst-release effect associated with drug-loaded cubosomes. The effectiveness of this approach was demonstrated through loading and release results from a model hydrophilic small molecule (fluorescein).
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| http://dx.doi.org/10.1021/la401660h | DOI Listing |
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