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The Relationship Between A High-Fat Diet, Gut Microbiome, and Systemic Chronic Inflammation: Insights from Integrated Multi-Omics Analysis.
Am J Clin Nutr
December 2024
Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Background: The detrimental effects of a high-fat diet (HFD) extend beyond metabolic consequences and include systemic chronic inflammation (SCI), immune dysregulation, and gut health disruption.
Objectives: In this study, we used Mendelian randomization (MR) to investigate the relationship between HFD and gut microbiota, and SCI.
Methods: Genetic variants associated with dietary fat were utilized to explore causal relationships.
Clinical and splenectomy-based treatment outcomes in 40 cases of hepatosplenic T-cell lymphoma: a comprehensive analysis.
World J Surg Oncol
December 2024
Department of Hematology, Huadong Hospital, Fudan University, No.221, Yan 'an West Road, Jing' an District, Shanghai, 200040, China.
Background/aim: This research study was conducted to examine the clinical characteristics and post-splenectomy survival outcomes of patients diagnosed with hepatosplenic T-cell lymphoma (HSTCL).
Materials And Methods: A total of 10 cases of HSTCL patients admitted to the Hematology Department of Fudan University Affiliated Huadong Hospital between January 2012 and December 2021 were included. In addition, we also included 30 other cases reported from domestic and international sources.
Hepatosplenic αβ T-cell lymphoma with peripheral blood involvement as initial presentation.
Ann Hematol
December 2024
Department of Laboratory Medicine, Hebei Yanda Lu Daopei Hospital, Sipulan Road, Yanjiao Development Area, Hebei, Langfang, 065201, China.
Long-Term Survival in Canine Hepatosplenic T-Cell Lymphoma Treated with Toceranib Phosphate Following Splenectomy: A Case of Atypical Lymphoma.
Vet Sci
October 2024
Laboratory of Clinical Diagnosis, Azabu University, Sagamihara 252-5201, Kanagawa, Japan.
Article Synopsis
- Toceranib phosphate is an approved treatment for canine mast cell tumors, but its long-term effectiveness for canine hepatosplenic T-cell lymphoma (HSTCL) has not been previously reported.
- A 10-year-old dog presented with weight loss and other symptoms, leading to the discovery of HSTCL through various tests and surgeries, including a splenectomy and liver biopsy.
- After starting toceranib treatment, the dog's liver enzyme levels decreased and it remained in good condition, demonstrating that toceranib may be a viable treatment option for HSTCL in dogs, with the dog surviving for 460 days post-treatment.
A prominent cutaneous eruption as a harbinger for aggressive systemic disease: Gamma-delta T-cell lymphoma.
JAAD Case Rep
September 2024
Department of Dermatology, Medical University of Graz, Graz, Austria.
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