A theoretical study of the emergence of helices in the wake of precipitation fronts is presented. The precipitation dynamics is described by the Cahn-Hilliard equation and the fronts are obtained by quenching the system into a linearly unstable state. Confining the process onto the surface of a cylinder and using the pulled-front formalism, our analytical calculations show that there are front solutions that propagate into the unstable state and leave behind a helical structure. We find that helical patterns emerge only if the radius of the cylinder R is larger than a critical value R>R(c), in agreement with recent experiments.
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http://dx.doi.org/10.1103/PhysRevE.88.022141 | DOI Listing |
Front Vet Sci
June 2024
Department of Population Health Sciences, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
Nucleic Acids Res
February 2024
Department of Bionanoscience, Kavli Institute of Nanoscience Delft, Delft University of Technology, Delft, South-Holland 2629HZ, The Netherlands.
Transcription-coupled supercoiling of DNA is a key factor in chromosome compaction and the regulation of genetic processes in all domains of life. It has become common knowledge that, during transcription, the DNA-dependent RNA polymerase (RNAP) induces positive supercoiling ahead of it (downstream) and negative supercoils in its wake (upstream), as rotation of RNAP around the DNA axis upon tracking its helical groove gets constrained due to drag on its RNA transcript. Here, we experimentally validate this so-called twin-supercoiled-domain model with in vitro real-time visualization at the single-molecule scale.
View Article and Find Full Text PDFMolecules
January 2023
Institute of Biomolecular Chemistry of CNR (ICB-CNR), Via F. Marzolo, 1, 35131 Padova, Italy.
The neuropeptides orexin A and B regulate various vital functions of the body, such as sleep/wake states, metabolism, and energy homeostasis. A loss of their physiological activity, with reduced ability to recognize their receptors, is suspected to be associated with oxidative stress conditions. These are related to excessive presence of reactive oxygen and nitrogen species, as well as of reactive lipoxidation byproducts.
View Article and Find Full Text PDFObjectives: 1) To assess long-term hearing results after endoskeletal ossicular chain reconstruction (eOCR) using the titanium Kraus K-Helix Crown prosthesis, implanted incus to stapes, with glass-ionomer cement (GIC) in chronic ears and 2) to determine safety of the prosthesis and cement.
Study Design: Prospective, nonrandomized, sequential, single center, single surgeon.
Setting: Private practice, ambulatory surgical center.
AAPS PharmSciTech
September 2022
School of Pharmacy, Jiangsu Vocational College of Medicine, Yancheng, 224005, China.
Nanoparticles based on bovine serum albumin (BSA), which shares 76% homology with human serum albumin (HSA), have emerged as a promising candidate for the efficient delivery of anticancer drugs. Thermal-driven self-assembly is a novel organic solvent-free approach to produce albumin nanoparticles. In our previous study, some features of this nanoparticle such as drug loading efficiency, drug encapsulation efficiency and drug release kinetics have been evaluated.
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