The purpose was to study consequences of long-duration (105-day) isolation and confinement on the rate of chromosomal aberrations in human blood lymphocytes in vivo. Blood samples for cytogenetic analysis were drawn from 6 test-subjects before and on completion of the experiment. Analysis of unstable chromosomal aberrations showed a statistically reliable increase (p < 0.05) in the rate of chromatid aberrations (virtually, 25-fold) in the form of single fragments as compared with baseline values. Rate of chromosome aberrations did not differ from baseline values except 1 test-subject with a dicentric and associated fragment found after the experiment.
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