AI Article Synopsis
- Lipopolysaccharide triggers an increase in TLR-1-8 mRNA levels in corneal fibroblasts, indicating a strong immune response.
- Researchers tested other TLR ligands and found that peptidoglycan also caused similar over-expression, while muramyldipeptide, lipoteichoic acid, and polyI:C did not.
- The findings imply that corneal fibroblasts can effectively recognize and respond to key microbial components, enhancing their defense mechanisms.
Article Abstract
Lipopolysaccharide induces TLR-1-8 mRNAs over-expression in corneal fibroblast. Analyzing if other TLR-ligands can do the same, we found that peptidoglycan does, but not muramyldipeptide, lipoteichoic acid and polyI:C. This suggests that the recognition of lipopolysaccharide and peptidoglycan is enough to alert these cells against microorganisms through the over-expression of the majority TLRs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768798 | PMC |
| http://dx.doi.org/10.1590/S1517-838220110003000025 | DOI Listing |
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