The described case of Wegener's granulomatosis evidences that this condition is difficult to diagnose and that it should be differentiated from tuberculosis, syphilis, pemphigus, deep mycosis. Late identification and beginning of therapy result in generalization of the process.
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This case study of Kongsfjorden, western coastal Svalbard, provides insights on how freshwater runoff from marine- and land-terminating glaciers influences the biogeochemical cycles and distribution patterns of carbon, nutrients, and trace elements in an Arctic fjord system. We collected samples from the water column at stations along the fjord axis and proglacial river catchments, and analyzed concentrations of dissolved trace elements, together with dissolved nutrients, as well as alkalinity and dissolved inorganic carbon. Statistical tools were applied to identify and quantify biogeochemical processes within the fjord that govern the constituent distributions.
View Article and Find Full Text PDF[Granulomatosis with polyangiitis. Analysis of two clinical cases from the practice of an otorhinolaryngologist].
Vestn Otorinolaringol
December 2024
Pavlov Ryazan State Medical University, Ryazan, Russia.
The article presents an analysis of 2 clinical cases of granulomatosis with polyangiitis from the practice of an otorhinolaryngologist. In the first case, the pathology manifested with lesions of the middle ear and nose. In the second case, in addition to manifestations from the nose and the ear, there was a lesion of the larynx.
View Article and Find Full Text PDFA Unique Case Linking Rituximab to a Ureaplasma Infection and Life-Threatening Hyperammonemia.
Cureus
November 2024
Pulmonary & Critical Care, Indiana University Health Methodist Hospital, Indianapolis, USA.
Rituximab is an anti-CD20 monoclonal antibody medication used in treating various cancers like non-Hodgkin lymphomas as well as immunologic conditions like granulomatosis with polyangiitis. It disrupts and decreases the number of B-cells, which causes an immunosuppressive state. This can promote the growth of numerous rare and opportunistic pathogens, one of which is .
View Article and Find Full Text PDFSignal detection and analysis of sulfasalazine adverse reaction events based on the US FDA adverse event reporting database.
Expert Opin Drug Saf
December 2024
Dongguan Key Laboratory of Stem Cell and Regenerative Tissue Engineering, The First Dongguan Affiliated Hospital, School of Basic Medical Sciences, Guangdong Medical University, Dongguan, China.
Background: Based on real data from the FDA Adverse Event Reporting System (FAERS), we explored and evaluated the adverse reactions (ADRs) of sulfasalazine (SSZ) in the first quarter of 2004-2023 to provide a reference basis and early warning for the safe use of SSZ in the clinic.
Research Design And Methods: The reporting odds ratio (ROR), the proportional reporting ratio (PRR), the Bayesian confidence propagation neural network (BCPNN), and the empirical Bayesian geometric mean (EBGM) were used as measures of SSZ-associated adverse events (AEs) signals, mining for potential positive signals between SSZ and AE.
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A Rare Case of Granulomatosis With Polyangiitis (Wegener's Granulomatosis) Presenting With Otologic Symptoms and Facial Paralysis.
Cureus
November 2024
Otolaryngology - Head and Neck Surgery, Affiliated Ear Nose and Throat Physicians, Woodstock, USA.
Granulomatosis with polyangiitis (GPA) is an uncommon disorder that causes inflammation of the blood vessels in the nose, throat, lungs, and kidneys. We describe a 20-year-old female who presented to the emergency room with acute left facial paralysis, worsening left-sided otalgia secondary to a hyperemic tympanic membrane with middle ear granulation tissue, nasal obstruction with associated intermittent epistaxis, and cough. A high index of suspicion for GPA helped make an early diagnosis with subsequent initiation of treatment.
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