This study was designed to evaluate the anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats. In the present study, anticonvulsant activities of paederosidic acid were evaluated by maximal electroshock and pentylenetetrazole-induced seizures in male mice. Then, pentobarbital sodium-induced sleeping time and locomotor activity tests in mice were used to evaluate the sedative effects of paederosidic acid. Finally, the mechanism of paederosidic acid was explored by evaluating the contents of Glu and GABA in the brain, and Western blot was used to measure GAD65 expression in the mouse brain. Paederosidic acid (5, 10, 20, and 40 mg/kg, ip) had significant anticonvulsant and sedative effects. Moreover, paederosidic acid increased brain gamma-aminobutyric acid and decreased glutamic acid in the brain, and it up-regulated expressions of GAD 65. In conclusion, our results suggest that paederosidic acid may be a promising future therapeutic agent for treatment of epilepsy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pbb.2013.08.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches.
Comb Chem High Throughput Screen
January 2025
KIPS, Shri Shankaracharya Professional University, Bhilai, Chhattisgarh, India.
The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine.
View Article and Find Full Text PDF-Iridoids: Occurrence, Chemophenetic Evaluation and Biological Activities-A Review.
Molecules
November 2024
Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", 00185 Rome, Italy.
In this work, the first review paper about -iridoids was presented. In particular, their detailed occurrence, chemophenetic evaluation and biological activities were reported. To the best of our knowledge, two hundred and eighty-eight -iridoids have been evidenced so far, bearing different structural features, with the link between two -iridoids sub-units as the major one.
View Article and Find Full Text PDFPaederosidic acid protect bone mass in lipopolysaccharide-treated rats by reducing oxidative stress and inflammatory.
Int Immunopharmacol
December 2024
Department of Pharmacy, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China. Electronic address:
Paederosidic acid (PA) has shown beneficial effects in anti-inflammatory studies, but it is unclear whether PA has positive impacts on bone loss induced by lipopolysaccharide (LPS). This study aims to investigate the influence of PA on bone loss in LPS-treated rats. The study assesses changes in the viability and osteogenic potential of MC3T3-E1 cells, as well as osteoclast differentiation in RAW264.
View Article and Find Full Text PDFCytotoxic iridoid glycosides from the leaves of .
J Asian Nat Prod Res
October 2024
Department of Endocrinology, General Hospital of Northern Theater Command, Shenyang 110840, China.
A phytochemical investigation on the 80% EtOH extract of the leaves of (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10----coumaroyl-(4,6)-3,4-dihydro-3-methylthiopaederoside (), 10---feruloyl-(4,6)-3,4-dihydro-2'--3-paederoside (), and 10---caffeoyl-paederosidic acid ethyl ester ().
View Article and Find Full Text PDFDetermination and Mechanism of Antidiarrheal Chemical Constituents of Determined by HPLC-ESI-MS Integrated with Network Pharmacology.
ACS Omega
August 2023
Heilongjiang International University, Harbin 150030, P. R. China.
is a natural medicinal plant that is widely used for its various pharmacological effects including antiviral, antitumor, anti-inflammatory, and antibacterial activities. However, there is no scientific evidence to support its antidiarrheal effect. In this study, the antidiarrheal activity of was evaluated using several validated models.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!