The polarity proteins LKB1 and SAD-A/B are key regulators of axon specification in the developing cerebral cortex. Recent studies now show that this mechanism cannot be generalized to other classes of neurons: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a later stage of axon development - arborization in the target field.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947747 | PMC |
| http://dx.doi.org/10.1016/j.cub.2013.07.073 | DOI Listing |
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