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Real-world switching patterns and associated characteristics in patients with psoriasis treated with biologics.
Arch Dermatol Res
January 2025
Department of Nursing, University of Peloponnese, Tripoli, 22100, Greece.
Multiple parameters define the treatment course with biologics for a psoriatic patient while treatment switches are often associated with worse prognosis. The purpose of this study was to describe the switching patterns of biologics for psoriasis in the Greek market landscape and to detect associated factors that may impact the evolvement of selected therapy. This is a retrospective cohort study using data recorded in the nationwide digital prescription database of Greece.
View Article and Find Full Text PDFImpact of antibiotic prophylaxis on gut microbiota in colorectal surgery: insights from an Eastern European stewardship study.
Front Cell Infect Microbiol
January 2025
Second Surgical Oncology Department, Regional Institute of Oncology, Iasi, Romania.
Introduction: Antibiotic overuse is driving a global rise in antibiotic resistance, highlighting the need for robust antimicrobial stewardship (AMS) initiatives to improve prescription practices. While antimicrobials are essential for treating sepsis and preventing surgical site infections (SSIs), they can inadvertently disrupt the gut microbiota, leading to postoperative complications. Treatment methods vary widely across nations due to differences in drug choice, dosage, and therapy duration, affecting antibiotic resistance rates, which can reach up to 51% in some countries.
View Article and Find Full Text PDFUnderstanding trends in osteoporosis drug prescribing: implications for reducing futile biomedical research.
Front Med (Lausanne)
January 2025
Department of Global Health and Social Medicine, Institute of Gerontology, Faculty of Social Science and Public Policy, King's College London, London, United Kingdom.
Introduction: Osteoporosis is a significant geriatric condition, considering its impact on fracture-related morbidity and mortality, particularly among older women. The interplay of clinical evidence, diagnostic tools availability, and broader societal attitudes toward aging and treatment efficacy affect medical attitude and prescribing behaviors. Using the example of osteoporosis in France and England, the study aims to unravel the intricacies of medical decision-making in geriatric care, offering insights into the evolving landscape of healthcare policy and practice, which in turn can help reduce futile biomedical research.
View Article and Find Full Text PDFPattern of antibiotic dispensing at pharmacies according to access, watch, reserve (AWaRe) classification: multicenter study after COVID-19 waves in different districts of Pakistan.
BMC Res Notes
January 2025
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 37000, Pakistan.
Objective: The dispensing of non-prescription antibiotics is a worldwide concern, and antibiotics should only be dispensed with a legitimate prescription.
Methodology: A cross-sectional study was conducted using the simulated client methodology, with data collected, recorded, and analyzed using SPSS.
Results: The simulated client visited 210 pharmacies, of which 70 dispensed antibiotics without a prescription.
Trend of the lipid profile in a cohort with severe hypercholesterolemia in Osona county (Barcelona, Spain), between 2009 and 2021.
BMC Public Health
January 2025
Laboratory Medicine, Clinical Laboratory, Vic University Hospital, Vic, Barcelona, Spain.
Background: Various studies confirm that the prevalence of dyslipidemia and other cardiovascular factors is high.
Objective: To evaluate the trend of the lipid profile (LP) in a cohort with severe hypercholesterolemia and its relationship with lipid-lowering treatment during the period 2009-2021.
Methods: Cross-sectional study carried out in the Osona county (Barcelona).
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