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Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood.
Antioxidants (Basel)
January 2025
Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli 41380, Turkey.
Maternal obesity is increasingly recognized as a risk factor for adverse fetal outcomes, primarily through its association with heightened oxidative stress. This study aimed to evaluate oxidative stress markers in umbilical cord blood of neonates born to obese mothers. Sixty-three pregnant women, who were of normal weight at the start of pregnancy but classified as obese at term, were included.
View Article and Find Full Text PDFFerroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq.
Antioxidants (Basel)
January 2025
Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, F-75006 Paris, France.
Medulloblastoma (MB) is the most common malignant brain tumor in children, typically arising during infancy and childhood. Despite multimodal therapies achieving a response rate of 70% in children older than 3 years, treatment remains challenging. Ferroptosis, a form of regulated cell death, can be induced in medulloblastoma cells in vitro using erastin or RSL3.
View Article and Find Full Text PDFDecline in global biodiversity intactness over the past two decades.
Sci Total Environ
January 2025
School of Artificial Intelligence, Anhui University, Hefei 230601, China.
Knowledge of the dynamics of biodiversity intactness and its spatial differentiation over different geographic regions of the world is crucial for the improved design of effective biodiversity conservation strategies. However, comprehensive investigations of the multiple indicators of biodiversity intactness across several spatial scales are lacking. The current study used an annual time series (2000-2020) of the biodiversity intactness index (BII) to investigate the mean magnitude, temporal trajectory, and relative changes in biodiversity intactness at the national, regional, and global levels.
View Article and Find Full Text PDFUsing Human-Centered Design to Bridge Zero-Dose Vaccine Gap: A Case Study of Ilala District in Tanzania.
Vaccines (Basel)
January 2025
Department of Preventive Services, Ministry of Health, Dodoma P.O. Box 743, Tanzania.
Immunization plays a substantial role in reducing the under-five mortality rate. However, Tanzania still has a significant number of zero-dose and under-vaccinated children and was ranked among the top ten African countries with the highest numbers of zero-dose children in 2022. The human-centered design (HCD) approach is more ethical and effective at addressing public health challenges in complex sociocultural settings.
View Article and Find Full Text PDFEffects of Pickleball Intervention on the Self-Esteem and Symptoms of Patients with Schizophrenia.
Sports (Basel)
January 2025
Department of Leisure and Recreation Management, Asia University, Taichung 41354, Taiwan.
Schizophrenia is classified by the World Health Organization (WHO) as one of the top ten diseases contributing to the global medical economic burden. Some studies have pointed out that exercise is effective for physical and mental health, as well as cognition. We hypothesized that participation in pickleball intervention would lead to improved self-esteem and reduced psychiatric symptoms in schizophrenia patients.
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