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http://dx.doi.org/10.4103/2249-4847.96742 | DOI Listing |
J Craniofac Surg
December 2024
Department of Endocrinology and Metabolism, West China Hospital, Chengdu, China.
This study aimed to explore the construction of experimental animal models replicating cartilage defects across diverse load-bearing sites, compare self-repair conditions, and examine the role of mechanical stimulation in cartilage self-repair. Experimental animal models were established in rabbits to simulate full-thickness cartilage defects without penetrating the subchondral bone, at various load-bearing sites, including the posterior femoral condyle, anterior femoral condyle and femoral trochlear of knee joint, and the humerus of the shoulder joint. The successful exposure and construction of cartilage defects at the anterior femoral condyle, femoral trochlear, and posterior femoral condyle through the medial extension of surgical incision.
View Article and Find Full Text PDFInt J Neonatal Screen
December 2024
Laboratory of Genomic, Epigenetics, Precision and Predictive Medicine, School of Medicine, Mohammed VI University of Sciences and Health, Casablanca 82403, Morocco.
Unlabelled: Newborn screening (NBS) represents an important public health measure for the early detection of specified disorders; such screening can prevent disability and death, not only from metabolic disorders but also from endocrine, hematologic, immune, and cardiac disorders. Screening for critical congenital conditions affecting newborns' health is a great challenge, especially in developing countries such as Morocco, where NBS program infrastructure is lacking. In addition, the consanguinity rate is high in Morocco.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
November 2024
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ischemic stroke is a major cause of mortality and disability and has become a significant public health concern among women. Overall, women have more ischemic stroke events than men, in part due to their longer life span, and also suffer from more severe stroke-related disabilities compared to men. Women are also more likely than men to present with atypical non-focal neurological symptoms, potentially leading to delayed diagnosis and treatment.
View Article and Find Full Text PDFJ Pers Med
December 2024
Cardiology Unit, Ospedale del Cuore, Fondazione Toscana "G. Monasterio", 54100 Massa, Italy.
Elderly patients with severe aortic stenosis (AS) need individualized decision-making in their management in order to benefit in terms of survival and improvement of quality of life. Frailty, a common condition in elderly patients, needs to be considered when weighing treatment options. We aimed to evaluate outcomes including survival and functional parameters according to disability criteria at six years of follow-up in an older population treated for severe AS using a frailty-based management.
View Article and Find Full Text PDFCurr Oncol
December 2024
Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, AB T2N 4Z6, Canada.
Background: Colorectal cancer is the third most common malignancy globally. Early-onset colorectal cancer (EOCRC) is becoming a growing healthcare focus globally, particularly in North America. We estimated trends in incidence, mortality, and disability-adjusted life years (DALYs) for EOCRC in Canada between 1990 and 2019.
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