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A practical access to highly enantiomerically pure flavanones by catalytic asymmetric transfer hydrogenation. | LitMetric

A practical access to highly enantiomerically pure flavanones by catalytic asymmetric transfer hydrogenation.

Angew Chem Int Ed Engl

Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden (Germany) http://www.chm.tu-dresden.de/oc1/

Published: October 2013

A surprisingly selective, non-enzymatic kinetic resolution of readily available, racemic β-chiral ketones enabled the title process, which was applied to a rapid synthesis of several bioactive flavanones in virtually enantiopure form (see scheme; MOM=methoxymethyl, Ts=p-toluenesulfonyl).

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http://dx.doi.org/10.1002/anie.201306500DOI Listing

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