Covariance structure analysis of nonnormal data is important because in practice all data are nonnormal. When applying covariance structure analysis to nonnormal data, it is generally assumed that the asymptotic covariance matrix Γ for the nonredundant terms in the sample covariance matrix S is nonsingular. It is shown this need not be the case, which raises a question of how restrictive this assumption may be and how difficult it may be to verify it. It is shown that Γ is nonsingular whenever sampling is from a nonsingular distribution, including any distribution defined by a density function. In the discrete case necessary and sufficient conditions are given for the nonsingularity of Γ, and it is shown how to demonstrate Γ is nonsingular with high probability. Thus, the nonsingularity of Γ assumption is mild and one should feel comfortable about making it. These observations also apply to the asymptotic covariance matrix Γ that arises in structural equation modeling.
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http://dx.doi.org/10.1007/s11336-013-9353-1 | DOI Listing |
CNS Neurosci Ther
January 2025
Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Background: Sudden sensorineural hearing loss (SSNHL) is associated with abnormal changes in the brain's central nervous system. Previous studies on the brain networks of SSNHL have primarily focused on functional connectivity within the brain. However, in addition to functional connectivity, structural connectivity also plays a crucial role in brain networks.
View Article and Find Full Text PDFUnlabelled: The biases revealed in protein sequence alignments have been shown to provide information related to protein structure, stability, and function. For example, sequence biases at individual positions can be used to design consensus proteins that are often more stable than naturally occurring counterparts. Likewise, correlations between pairs of residue can be used to predict protein structures.
View Article and Find Full Text PDFBiostatistics
December 2024
Department of Biostatistics, Yale University School of Public Health, 60 College Street, New Haven, CT06511, United States.
Evaluating air quality interventions is confronted with the challenge of interference since interventions at a particular pollution source likely impact air quality and health at distant locations, and air quality and health at any given location are likely impacted by interventions at many sources. The structure of interference in this context is dictated by complex atmospheric processes governing how pollution emitted from a particular source is transformed and transported across space and can be cast with a bipartite structure reflecting the two distinct types of units: (i) interventional units on which treatments are applied or withheld to change pollution emissions; and (ii) outcome units on which outcomes of primary interest are measured. We propose new estimands for bipartite causal inference with interference that construe two components of treatment: a "key-associated" (or "individual") treatment and an "upwind" (or "neighborhood") treatment.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
January 2025
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:
There is a much debate regarding optimal selection in patients with metastatic cancer who should undergo local treatment (surgery or radiation treatment) to the primary tumor and/or metastases. Additionally, the optimal treatment of newly diagnosed metastatic cancer is largely unclear. Current prognostication systems to best inform these clinical scenarios are limited, as all metastatic patients are grouped together as having Stage IV disease without further incorporation of patient and disease-specific covariates that significantly impact patient outcomes.
View Article and Find Full Text PDFBMJ Open Diabetes Res Care
January 2025
Diabetes and Endocrinology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK
Introduction: The UK national pediatric diabetes audit reports higher HbA1c for children and young people (CYP) with type 1 diabetes (T1D) of Black ethnicity compared with White counterparts. This is presumably related to higher mean blood glucose (MBG) due to lower socioeconomic status (SES) and less access to technology. We aimed to determine if HbA1c ethnic disparity persists after accounting for the above variables.
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