The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813850 | PMC |
| http://dx.doi.org/10.1534/genetics.113.156372 | DOI Listing |
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