Laser-plasma particle accelerators could provide more compact sources of high-energy radiation than conventional accelerators. Moreover, because they deliver radiation in femtosecond pulses, they could improve the time resolution of X-ray absorption techniques. Here we show that we can measure and control the polarization of ultra-short, broad-band keV photon pulses emitted from a laser-plasma-based betatron source. The electron trajectories and hence the polarization of the emitted X-rays are experimentally controlled by the pulse-front tilt of the driving laser pulses. Particle-in-cell simulations show that an asymmetric plasma wave can be driven by a tilted pulse front and a non-symmetric intensity distribution of the focal spot. Both lead to a notable off-axis electron injection followed by collective electron-betatron oscillations. We expect that our method for an all-optical steering is not only useful for plasma-based X-ray sources but also has significance for future laser-based particle accelerators.
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http://dx.doi.org/10.1038/ncomms3421 | DOI Listing |
Phys Rev Lett
December 2024
Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
We measure the high-intensity laser propagation throughout meter-scale, channel-guided laser-plasma accelerators by adjusting the length of the plasma channel on a shot-by-shot basis, showing high-quality guiding of 500 TW laser pulses over 30 cm in a hydrogen plasma of density n_{0}≈1×10^{17} cm^{-3}. We observed transverse energy transport of higher-order modes in the first ≈12 cm of the plasma channel, followed by quasimatched propagation, and the gradual, dark-current-free depletion of laser energy to the wake. We quantify the laser-to-wake transfer efficiency limitations of currently available petawatt-class lasers and demonstrate via simulation how control over the laser mode can significantly improve beam parameters.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India.
Background: Vascular Dementia (VaD) is the second most prevalent cause of dementia, arising from the blockage of blood vessels in the brain. One event responsible for the blockage or narrowing of small blood vessels is transient ischemic attack (TIA), and these changes resolve within 24 hours in humans. The molecular mechanism underlying these changes in recovery in small vessels still needs to be investigated.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Synaptic plasticity impairment plays a critical role in the pathogenesis of Alzheimer's disease (AD), Smad4, a central intracellular signal transmission mediator of transmission of transforming growth factor-β (TGF-β) signaling, plays a pivotal role in many biological processes, including cell differentiation, migration, apoptosis and tumorigenesis. Emerging evidence has demonstrated that Smad4 is also involved in the pathogenesis of AD. Once TGF-β signaling is stimulated, Smad4 interaction with Sp1 and Smad3 induces the transcriptional activation of APP.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Sandia National Laboratories, PO Box 5800, Albuquerque, New Mexico 87185, USA.
Magnetic insulation of electrons prevents losses and can be applied to generating radiation or electron sources for high current and high power applications. Ion emission from the anode may degrade magnetic insulation. We develop equilibrium theory, self-consistently coupling magnetically insulated electron flow with free-flowing injected ions.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing Key Laboratory of Chinese Materia Pharmacology, National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases, Beijing, China.
Introduction: Ischemic stroke greatly threatens human life and health. Neuro-restoration is considered to be the critical points in reestablishing neurological function and improving the quality of life of patients. Catalpol is the main active ingredient of the Chinese herbal medicine , which has the beneficial efficacy in traditional remedy, is closely related to the mitochondrial morphology and function.
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