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Valvular heart disease: from mechanisms to management.
Lancet
April 2024
Heart Vascular and Thoracic Institute, Cleveland Clinic London, London, UK; Department of Cardiology, St Thomas' Hospital, London, UK.
Valvular heart disease is common and its prevalence is rapidly increasing worldwide. Effective medical therapies are insufficient and treatment was historically limited to the surgical techniques of valve repair or replacement, resulting in systematic underprovision of care to older patients and those with substantial comorbidities, frailty, or left ventricular dysfunction. Advances in imaging and surgical techniques over the past 20 years have transformed the management of valvular heart disease.
View Article and Find Full Text PDFFirst experience with the new extracorporeal membrane oxygenation system Colibrì.
Artif Organs
January 2024
Department of Cardiac Surgery, University Hospital Halle, Halle (Saale), Germany.
Introduction: Extracorporeal membrane oxygenation (ECMO) is increasingly used for circulatory or pulmonary support not only in-hospital but also out-of-hospital. Small dimensions and a lightweight design are important, especially for out-of-hospital use but also for intra-hospital transportation of patients who require ECMO support. We share our first experience with the new Colibrì ECMO system.
View Article and Find Full Text PDFTranscatheter heart valve commissural alignment: an updated review.
Front Cardiovasc Med
April 2023
Ramsay Générale de Santé, Institut Cardiovasculaire Paris Sud, Interventional Cardiology Department, Massy, France.
Transcatheter aortic valve replacement (TAVR) indications recently extended to lower surgical risk patients with longer life expectancy. Commissural alignment (CA) is one of the emerging concepts and is becoming one of the cornerstones of the TAVR procedure in a patient with increased longevity. Indeed, CA may improve transcatheter heart valve (THV) hemodynamics, future coronary access, and repeatability.
View Article and Find Full Text PDFExpert consensus recommendations for the provision of infective endocarditis services: updated guidance from the Joint British Societies.
Heart
August 2023
Cardiology department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Infective endocarditis (IE) remains a difficult condition to diagnose and treat and is an infection of high consequence for patients, causing long hospital stays, life-changing complications and high mortality. A new multidisciplinary, multiprofessional, British Society for Antimicrobial Chemotherapy (BSAC)-ledWorking Party was convened to undertake a focused systematical review of the literature and to update the previous BSAC guidelines relating delivery of services for patients with IE. A scoping exercise identified new questions concerning optimal delivery of care, and the systematic review identified 16 231 papers of which 20 met the inclusion criteria.
View Article and Find Full Text PDFImpact of Medication Nonadherence in a Clinical Trial of Dual Antiplatelet Therapy.
J Am Coll Cardiol
August 2022
CTU Bern, University of Bern, Bern, Switzerland.
Article Synopsis
- Nonadherence to antiplatelet therapy is prevalent among patients after percutaneous coronary intervention (PCI), even in clinical trials like the MASTER DAPT study aimed at high bleeding risk individuals.
- The study involved 4,579 patients randomized to receive either abbreviated or standard dual antiplatelet therapy, examining outcomes such as adverse clinical events and bleeding risks.
- Results showed that while adherence levels varied, the abbreviated treatment led to similar levels of adverse events but significantly reduced major bleeding compared to standard treatment.
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