AI Article Synopsis
- This paper explores tip-enhanced Raman spectroscopy (TERS) of phospholipid bilayers in water, focusing on DPPC and DOPC membranes.
- Researchers developed durable alumina- and silver-coated tungsten tips for use in this environment.
- The study found significant time-dependent spectral changes in DOPC bilayers due to their fluid nature, suggesting that time-resolved TERS could effectively analyze fluidity and diffusion in these membranes.
Article Abstract
Tip-enhanced Raman spectroscopy (TERS) of supported phospholipid bilayers in an aqueous environment is discussed in this paper. Two bilayer membranes were examined: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). We fabricated alumina- and silver-coated tungsten tips that are very robust in water. There was a large time-dependence in the TERS spectra for the DOPC bilayers, whereas no such time-dependence was observed in the DPPC bilayer spectra under the probe tip. The spectral changes of DOPC bilayers are discussed in terms of the fluidity of the liquid crystalline phase. Time-resolved TERS thus has the potential to characterize inhomogeneity and diffusion in fluidic phospholipid bilayer membranes.
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| http://dx.doi.org/10.2116/analsci.29.865 | DOI Listing |
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