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On modes of disease transmission and the hidden shape of pandemics: A review of by Joshua Weitz.
Virus Evol
December 2024
Department of Ecology and Evolutionary Biology, Yale University, 165 Prospect Street, New Haven, CT 06511, USA.
The importance of asymptomatic transmission was a key discovery in our efforts to study and intervene in the COVID-19 pandemic. In (Johns Hopkins University Press, 2024), Joshua Weitz uses this aspect of SARS-CoV-2 natural history to discuss many counterintuitive characteristics of the pandemic. In this essay, I engage the arguments in the book, and discuss why asymptomatic transmission is such a critical dimension of the study of infectious diseases.
View Article and Find Full Text PDF[How I treat…the cardiogenic acute pulmonary oedema].
Rev Med Liege
December 2024
Service des Urgences, CHC Mont Légia, Liège, Belgique.
In the context of Acute Pulmonary Edema (APE), the old school moto was LMNOP, for "Lasix-Morphine-Nitrates-Oxygen-Positive Pressure". However, this mnemonic, while not entirely inaccurate, deserves revision or at least a slight reinterpretation. APE remains a well-known condition in emergency departments, with a high mortality rate.
View Article and Find Full Text PDFClimbing the : The cost of growing animals great and small.
Proc Natl Acad Sci U S A
December 2024
Institute of Evolution, Hungarian Research Network Centre for Ecological Research, Budapest 1113, Hungary.
Anisogamy and sex roles: a commentary.
Evol Lett
December 2024
Department of Life Sciences, Milner Centre for Evolution, University of Bath, Bath BA2 7AY, United Kingdom.
The origin and maintenance of sex differences in reproductive behavior (often labeled sex roles) have remained controversial topics, and recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles. We are glad to see that our study (Mokos et al., 2021) generated a healthy debate, and in agreement with recent commentaries (Janicke, 2024; Lehtonen & Parker, 2024) we call for a more comprehensive approach to understanding sex role evolution.
View Article and Find Full Text PDFT-switch-ing TCR specificity.
Immunity
December 2024
Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at the University of California Los Angeles (UCLA), Los Angeles, CA, USA; Department of Microbiology, Immunology, and Molecular Genetics at the University of California Los Angeles (UCLA), Los Angeles, CA, USA; Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center-UCLA, Los Angeles, CA, USA; Broad Stem Cell Research Center-UCLA, Los Angeles, CA, USA. Electronic address:
Central tolerance restricts T cells that target self-antigens. In this issue of Immunity, Abdelfattah et al. describe a method to generate self-reactive T cell receptors (TCRs) by directed evolution of non-autoreactive TCRs to recognize self-antigen peptides and demonstrate potential for T cells engineered with such receptors in immunotherapy.
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