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Influence of forage-to-concentrate ratio on the effects of a radiata pine bark extract on methane production and fermentation using the rumen simulation technique.
Animal
December 2024
Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Campus Chillán, Chillán 3812120, Chile. Electronic address:
Climate change and food safety standards have intensified research into plant-based compounds as alternatives to dietary supplements in animal feed. These compounds can reduce enteric methane (CH) emissions and the formation of ruminal ammonia. This study investigated the effects of radiata pine bark extract (PBE) supplementation on CH production, ruminal fermentation parameters, and nutrient disappearance using the rumen simulation technique in diets with different forage-to-concentrate (F:C) ratios.
View Article and Find Full Text PDFBiomimetic wrinkled prebiotic microspheres with enhanced intestinal retention for hyperphosphatemia and vascular calcification.
Sci Adv
January 2025
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
It is urgent for patients with chronic kidney disease (CKD) to develop a robust and facile therapy for effective control of serum phosphate and reasonable regulation of gut microbiota, which are aiming to prevent cardiovascular calcification and reduce cardiovascular complications. Here, bioinspired by intestinal microstructures, we developed biomimetic wrinkled prebiotic-containing microspheres with enhanced intestinal retention and absorption for reducing hyperphosphatemia and vascular calcification of CKD model rats. The resultant CSM@5 microspheres exhibited favorable phosphate binding capacity in vitro and could effectively reduce serum concentration of phosphorous in vivo.
View Article and Find Full Text PDFEvaluating the Effect of Vitamin D Supplementation on Type 2 Diabetes Risk: A Systematic Review.
Cureus
December 2024
Family Medicine, Najran Armed Forces Hospital, Najran, SAU.
Although observational studies have linked vitamin D deficiency to diabetes, it is unknown if taking vitamin D supplements can reduce the chance of developing type 2 diabetes mellitus (T2DM). The purpose of this systematic review is to determine whether vitamin D supplementation lowers the risk of type 2 diabetes. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to search for studies based on pre-established inclusion and exclusion criteria.
View Article and Find Full Text PDFQuantitative Assessment of Postural Influence on Lung Function Using Deformable Image Registration-Based Breath-Hold CT Ventilation Imaging.
Cureus
December 2024
Department of Radiological Technology, Fujieda Municipal General Hospital, Fujieda, JPN.
Purpose This study aimed to clarify which positions are beneficial for patients with pathological lung diseases, such as acute respiratory distress syndrome, by obtaining lung ventilation and deformable vector field (DVF) images using Deformable Image Registration (DIR). Methods Thirteen healthy volunteers (5 female, 8 male) provided informed consent to participate to observe changes in normal lungs. DIR imaging was processed using the B-spline algorithm to obtain BH-CTVI (inhale, exhale) in four body positions (supine, prone, right lateral, left lateral) using DIR-based breath-hold CT ventilation imaging (BH-CTVI).
View Article and Find Full Text PDFBrainFit: improving executive and subjective cognitive functioning in late-life mood disorders - a double-blind randomized active-controlled study evaluating the effect of online cognitive training.
Front Psychiatry
January 2025
Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Introduction: Unipolar and bipolar mood disorders in older adults are accompanied by cognitive impairment, including executive dysfunction, with a severe impact on daily life. Up and till now, strategies to improve cognitive functioning in late-life mood disorders (LLMD) are sparse. Therefore, we aimed to assess the efficacy of adaptive, computerized cognitive training (CT) on executive and subjective cognitive functioning in LLMD.
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