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Alkaline Mineral Complex Water Attenuates Transportation-Induced Hepatic Lipid Metabolism Dysregulation by AMPKα-SREBP-1c/PPARα Pathways.
Int J Mol Sci
October 2024
College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
Transportation, an unavoidable process in livestock farming, causes metabolic disorders in the body, which then lead to endocrine disruption, being immunocompromised, and growth suppression. Lipid metabolism dysregulation is a critical phenotype induced by transportation. The liver is a vital organ in lipid metabolism, with a role in both lipid synthesis and lipolysis.
View Article and Find Full Text PDFExtending the Carbon Chain Length of Carbohydrate-Derived 5-Substituted-2-furaldehydes by Condensing with Active Methylene Compounds under Organocatalytic Conditions.
ACS Omega
September 2024
Department of Chemistry, National Institute of Technology Karnataka (NITK), Surathkal, Mangalore 575025, Karnataka, India.
This work reports a high-yielding, organic solvent-free, gram-scale synthesis of novel Knoevenagel condensation products by reacting carbohydrate-derived 5-substituted-2-furaldehydes (SFLs) with active methylene compounds (AMCs) using various organic amines and inorganic bases as catalysts. Among the base catalysts examined, piperidine performed best, affording satisfactory selectivity and yield of the targeted Knoevenagel condensation products owing to the subtle balance between its nucleophilicity and basicity. The reaction was optimized on various reaction parameters, such as temperature, duration, solvent, catalyst loading, and molar ratio of the reactants.
View Article and Find Full Text PDFGovernance of Electronic Health Record Modification at U.S. Academic Medical Centers.
Appl Clin Inform
October 2023
Department of Medicine, University of California, San Francisco, San Francisco, California, United States.
Objectives: A key aspect of electronic health record (EHR) governance involves the approach to EHR modification. We report a descriptive study to characterize EHR governance at academic medical centers (AMCs) across the United States.
Methods: We conducted interviews with the Chief Medical Information Officers of 18 AMCs about the process of EHR modification for standard requests.
How Academic Medical Centers Can Navigate the Pandemic and Its Aftermath: Solutions for 3 Major Issues.
Acad Med
November 2021
P.A. Pizzo is David and Susan Heckerman Professor of Pediatrics and of Microbiology and Immunology, former dean, Stanford School of Medicine, and founding director, Stanford Distinguished Careers Institute, Stanford University, Stanford, California; ORCID: https://orcid.org/0000-0002-1000-6516 .
The COVID-19 crisis has seriously affected academic medical centers (AMCs) on multiple levels. Combined with many trends that were already under way pre pandemic, the current situation has generated significant disruption and underscored the need for change within and across AMCs. In this article, the authors explore some of the major issues and propose actionable solutions in 3 areas of concentration.
View Article and Find Full Text PDFResidency training in the time of COVID-19: A framework for academic medical centers dealing with the pandemic.
Perspect Med Educ
March 2021
Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Background: As cases of COVID-19 climb worldwide, academic medical centers (AMCs) are scrambling to balance the increasing demand for medical services while maintaining safe learning environments. The scale and nature of the current pandemic, limitations on key resources, risks of transmission, and the impact on trainee wellbeing pose additional challenges to AMCs. We propose a framework for AMCs to utilize in facilitating health system, organization and program-level adjustments to meet the needs of medical trainees during the pandemic.
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