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From the University of Cincinnati, College of Medicine, OH (D.W., J.O., M.F.); Massachusetts General Hospital, Harvard Medical School, Boston, MA (J.R.); Department of Neurology, Georgetown University Medical Center, Washington, DC (C.K.); John P. Hussman Institute for Human Genomics, University of Miami, FL (J.L.M., S.E.W.); Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (M.W.B., C.D.L.); Institute for Policy Research, University of Cincinnati, OH (E.W.R.); National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.W., J.N.R.); University of Miami, Miller School of Medicine, FL (S.K., R.I.S.); University of Texas Medical School-Houston, TX (N.R.G., R.M.); University of Southern California, Neurocritical Care and Stroke Division, Los Angeles, CA (G.S.); University of Maryland, Baltimore Veterans Administration Medical Center, MD (S.K.); University of Texas Health Science Center at San Antonio, TX (L.B., F.J., A.L.); Emory University, Grady Memorial Hospital, Atlanta, GA (M.F.); University of Illinois at Chicago Medical Center, IL (F.D.T.); Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX (C.E.H.); Columbia University, New York, NY (M.S.V.E.); University of Arizona, Tucson, AZ (B.C.); St. Luke's-Roosevelt Hospital Center, New York, NY (J.Y.C.); University of California San Francisco, Fresno, CA (T.W.); University of New Mexico, Albuquerque, NM (M.M.); Department of Anesthesiology, Duke University, Durham, NC (M.L.J.); University of California, Los Angeles, CA (L.K.A.); Department of Neurology and Public Health Sciences, University of Virginia, Charlottesville, VA (B.B.W.); and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD (T.W.).
Published: October 2013
AI Article Synopsis
Article Abstract
Background And Purpose: Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH.
Methods: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case-control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region.
Results: As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation.
Conclusions: The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.
