Ingestion of raw or undercooked shiitake mushrooms is associated with a distinctive flagellate erythema. We describe a 61-year-old Caucasian man who presented with a pruritic, erythematous eruption of multiple linear streaks on the trunk and extremities starting 1 day after eating raw shiitake mushrooms. His symptoms and skin lesions resolved with minimal hyperpigmentation within approximately 1 week after treating with topical steroids and oral antihistamines. Skin biopsy showed non-specific findings, including a sparse perivascular and interstitial dermatitis as well as focal vacuolar interface changes. Our case illustrates that this condition is a visibly striking dermatitis with a self-limited course. The pathomechanism of the skin eruption remains unclear.

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Article Synopsis
  • - Shiitake mushroom-induced flagellate dermatitis is an uncommon skin condition that can occur after eating shiitake mushrooms and leads to itchy rashes.
  • - Prompt diagnosis and treatment with oral and topical steroids are important for easing symptoms and avoiding further issues.
  • - It’s crucial for healthcare providers to recognize the rash and its timing after mushroom eating, as well as to inform patients about the risks of consuming raw or undercooked shiitake mushrooms to prevent future cases.
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Article Synopsis
  • Flagellate erythema, also known as shiitake dermatitis, is a rare skin condition that causes red, linear lesions resembling whip marks, often triggered by eating raw or undercooked shiitake mushrooms.
  • A case involving a 31-year-old African American male highlights symptoms like itchy, red, and pigmented lesions on his face and body after consuming shiitake mushrooms.
  • Diagnosis mainly depends on patient history rather than biopsy, and treatment focuses on relief through topical steroids and antihistamines, as most cases resolve within three weeks.
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Flagellate dermatitis in a patient with testicular germ cell neoplasia on bleomycin.

Dermatol Reports

December 2023

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Bleomycin, an antineoplastic antibiotic that inhibits DNA synthesis, is used to treat various malignant tumors such as Hodgkin's lymphoma, squamous cell carcinoma, and germ cell tumors. Flagellate erythema is a rare rash with a linear pattern that has been observed in association with bleomycin treatment. Herein, we present a 43-year-old patient with metastatic testicular cell neoplasms who developed a whiplash rash during treatment with a chemotherapy regimen that included bleomycin.

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