AI Article Synopsis
- The study evaluated the impact of a 1-year treatment with an estradiol valerate/dienogest pill on 36 women with polycystic ovary syndrome and varying grades of acne.
- After 12 months, 52.8% of the participants showed improvement in their acne, while 8.4% experienced worsening, with results considered statistically significant.
- Levels of sex hormone-binding globulin (SHBG) increased significantly, while total testosterone levels decreased, indicating a potential positive effect on acne and hyperandrogenism; however, further larger studies are needed to confirm these findings.
Article Abstract
This study shows the effect of a 1 year treatment with an estradiol valerate/dienogest pill in 36 women suffering from polycystic ovaries and mild or moderate acne. At beginning of the study, 24 patients (66.7%) had grade 1-2 (mild) acne and 12 patients (33.3%) had grade 3 (moderate) acne. After 12 cycles of therapy, we found an improvement of acne in 19 (52.8%) patients and a worsening of acne in 3 (8.4%) patients. The percentage of patients recovered was statistically significant (p < 0.01). SHBG levels were significantly higher after 6 and 12 months of therapy (p < 0.001), while total testosterone levels were lower in all patients at 6 and 12 months although this trend did not reach statistical significance. In conclusion, the present study suggests that the E2V/DNG pill could exert a positive influence on acne and hyperandrogenism. Since this is an observational study on a very limited population number, additional randomized controlled studies on larger populations are needed also to determine the effects of this contraceptive over longer periods of use.
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| http://dx.doi.org/10.3109/09513590.2013.831834 | DOI Listing |
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