Systems factorial technology (SFT) comprises a set of powerful nonparametric models and measures, together with a theory-driven experiment methodology termed the double factorial paradigm (DFP), for assessing the cognitive information-processing mechanisms supporting the processing of multiple sources of information in a given task (Townsend and Nozawa, Journal of Mathematical Psychology 39:321-360, 1995). We provide an overview of the model-based measures of SFT, together with a tutorial on designing a DFP experiment to take advantage of all SFT measures in a single experiment. Illustrative examples are given to highlight the breadth of applicability of these techniques across psychology. We further introduce and demonstrate a new package for performing SFT analyses using R for statistical computing.
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http://dx.doi.org/10.3758/s13428-013-0377-3 | DOI Listing |
World J Diabetes
January 2025
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20810, United States.
Diabetes mellitus (DM) is a debilitating disorder that impacts all systems of the body and has been increasing in prevalence throughout the globe. DM represents a significant clinical challenge to care for individuals and prevent the onset of chronic disability and ultimately death. Underlying cellular mechanisms for the onset and development of DM are multi-factorial in origin and involve pathways associated with the production of reactive oxygen species and the generation of oxidative stress as well as the dysfunction of mitochondrial cellular organelles, programmed cell death, and circadian rhythm impairments.
View Article and Find Full Text PDFEndocr Metab Immune Disord Drug Targets
January 2025
Amity Institute of Pharmacy, Amity University Haryana Chemistry Gurugram India.
Objectives: In the last two decades, scientists have gained a better understanding of several aspects of pituitary development. The signaling pathways that govern pituitary morphology and development have been identified, and the compensatory relationships among them are now known.
Aims: This paper aims to emphasize the wide variety of relationships between Pituitary Gland and Stem cells in hormone Production and disease prevention.
Microbiol Spectr
January 2025
Complex Microbial Systems Group, National Institute of Standards and Technology (NIST), Gaithersburg, Maryland, USA.
The experimental methods employed during metagenomic sequencing analyses of microbiome samples significantly impact the resulting data and typically vary substantially between laboratories. In this study, a full factorial experimental design was used to compare the effects of a select set of methodological choices (sample, operator, lot, extraction kit, variable region, and reference database) on the analysis of biologically diverse stool samples. For each parameter investigated, a main effect was calculated that allowed direct comparison both between methodological choices (bias effects) and between samples (real biological differences).
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Arar, Saudi Arabia.
Introduction: Rhein, a natural bioactive lipophilic compound with numerous pharmacological activities, faces limitations in clinical application due to poor aqueous solubility and low bioavailability. Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.
Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 3 factorial design.
Transl Anim Sci
January 2025
Lethbridge Research and Development Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta T1J 4B1, Canada.
A study was conducted to assess growth performance, methane (CH) emissions, and feeding behavior of feedlot steers consuming backgrounding and finishing diets with an essential oil blend (EO), monensin (Mon), and their combination (EO + Mon). The study was structured as a 2 × 2 factorial, with two feed additive treatments (Control, EO) and two monensin treatments (no Monensin, Monensin). One hundred Angus × steers were evenly distributed across each treatment into four pens, and each dietary phase consisted of four, 28-d periods.
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