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Association of HPA Antigens with Immune Thrombocytopenia: A Case-Control Study by PCR-SSP Method.
Int J Hematol Oncol Stem Cell Res
October 2024
Department of Immunology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Human platelet antigens (HPAs) play a clinically significant role in alloimmunization and the development of immune-mediated disorders such as immune thrombocytopenia (ITP), fetal and neonatal alloimmune thrombocytopenia (FNAIT), and post-transfusion purpura (PTP). Understanding the genetic profiles of HPAs is critical for preventing and treating these conditions. Given the limitations of serological methods in determining HPA genotypes, this study aims to investigate the association between the genotypes of HPA1, HPA2, HPA3, HPA4, and HPA15 antigens and autoimmune thrombocytopenia in Lorestan Province, utilizing the PCR-SSP method.
View Article and Find Full Text PDFABO-identical versus incompatible platelet transfusion in patients with intracranial hemorrhage.
PLoS One
November 2024
Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, United States of America.
Article Synopsis
- The study investigates the effects of ABO compatibility on platelet transfusion outcomes in patients with spontaneous and traumatic intracranial hemorrhage (ICH).
- It hypothesizes that ABO-identical transfusions would result in better post-transfusion platelet increments and improved neurologic outcomes compared to incompatible transfusions.
- Results show no significant differences in platelet increments or clinical outcomes among patients receiving ABO-identical, major incompatible, or minor incompatible transfusions, suggesting ABO compatibility may not be as crucial as previously thought.
The role of protein kinase C and the glycoprotein Ibα cytoplasmic tail in anti-glycoprotein Ibα antibody-induced platelet apoptosis and thrombocytopenia.
Thromb Res
December 2024
Jiangsu Institute of Hematology, Cyrus Tang Medical Institute, The First Affiliated Hospital Collaborative Innovation Center of Hematology, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, National Clinical Research Center for Hematological Diseases, Suzhou, China. Electronic address:
Introduction: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts. ITP patients with anti-platelet glycoprotein (GP) Ibα (a subunit of GPIb-IX-V complex) autoantibodies, which induce Fc-independent signaling and platelet clearance, are refractory to conventional treatment. Protein kinase C (PKC) is activated by the binding of the ligand von Willebrand factor (VWF) to GPIbα and regulates VWF-GPIbα-induced platelet activation.
View Article and Find Full Text PDFAnalysis of platelet transfusion efficacy during extracorporeal membrane oxygenation (ECMO) treatment in pediatric patients post-cardiac surgery-a retrospective cohort study.
Lab Med
November 2024
Department of Blood Transfusion, The First Affiliated Hospital of Tsinghua University, Beijing, China.
Article Synopsis
- - This study investigates the impact of platelet transfusions on pediatric patients undergoing extracorporeal membrane oxygenation (ECMO) after cardiac surgery, focusing on minimizing risks of thrombocytopenia and bleeding.
- - Researchers analyzed data from 11 patients who received a total of 47 platelet transfusions, assessing the effectiveness using the corrected count increment (CCI) before and 24 hours post-transfusion.
- - Findings revealed that only 46.8% of the transfusions were effective, and patients were categorized based on their pretransfusion platelet counts to evaluate the efficacy of varying transfusion thresholds.
Frequency of human platelet antigens (HPA) in the Greek population as deduced from the first registry of HPA-typed blood donors.
Vox Sang
December 2024
Blood Center, AHEPA University General Hospital of Thessaloniki, Thessaloniki, Greece.
Background And Objectives: Human platelet antigens (HPA) play a central role in foetal and neonatal alloimmune thrombocytopenia (FNAIT), post-transfusion purpura and some cases of platelet therapy refractoriness. The frequency distribution of HPA had not been studied in the Greek population before we started to create a registry of HPA-typed apheresis platelet donors. The aim of this study was the determination of the frequency of various HPA in the Greek population, through the establishment of a registry of typed donors.
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