Synthesis of amines with pendant boronic esters by borrowing hydrogen catalysis.

Org Lett

Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, U.K.

Published: September 2013

AI Article Synopsis

  • Amine alkylation reactions involving alcohols were conducted with boronic ester groups, resulting in products that can serve as molecular sensors.
  • The boronic ester could be included in either the alcohol or the amine starting materials.
  • The presence of a ruthenium catalyst did not affect the stability of the boronic ester during these reactions.

Article Abstract

Amine alkylation reactions of alcohols have been performed in the presence of boronic ester groups to provide products which are known to have use as molecular sensors. The boronic ester moiety could be present in either the alcohol or amine starting material and was not compromised in the presence of a ruthenium catalyst.

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Source
http://dx.doi.org/10.1021/ol402271aDOI Listing

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