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Multiple pregnancies are infrequently encountered, with the incidence of spontaneous triplet pregnancies estimated at approximately 1 in 7000 pregnancies. Triplet gestations are recognized for their propensity to bring about a spectrum of pregnancy related complexities, encompassing fetal structural abnormalities, neurological anomalies, disturbances in amniotic fluid levels, preterm labor, and suboptimal neonatal outcomes. Anencephaly is a serious congenital defect where the brain and skull do not fully develop, often leading to a poor prognosis.
View Article and Find Full Text PDFNeural tube defects and uterus development in human fetuses.
Sci Rep
August 2022
Urogenital Research Unit, State University of Rio de Janeiro, Rua Professor Gabizo, 104/201, Tijuca, Rio de Janeiro, RJ, CEP 20271-320, Brazil.
One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important.
View Article and Find Full Text PDFThe Moro reflex: insights into the pathophysiology of generalized tonic-clonic seizures and infantile spasms.
Epileptic Disord
October 2022
Centre for Cognitive Neuroscience, European Reference Network EpiCARE, Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University of Salzburg, Salzburg, Austria
The Moro reflex (MR) is a primitive reflex that disappears after the first three months of life. It was described by the Austrian paediatrician Ernst Moro (1874-1951) in 1918, although the earliest visual representation of the MR dates back to the first half of the 14th Century, in a fresco by Ambrogio Lorenzetti (1290-1348). The neural centre underlying the MR is located in the lower part of the brainstem since it can be elicited also in anencephalic infants, as shown by the Austrian neurologist Eduard Gamper (1887-1938) in the first medical description of anencephaly (1926).
View Article and Find Full Text PDFA Revised Moral Appraisal of Early Induction of Labor in Cases of Anencephaly.
HEC Forum
December 2023
Ethics Educator, Mission Services, PeaceHealth, Vancouver, WA, USA.
The central concern of this article is whether early induction of labor for an anencephalic fetus can ever be morally justified, particularly by a Catholic healthcare ethics committee. By revisiting and refining arguments in articles by Drane (1992) and Bole (1992) published in this journal, a revised argument - consistent with the Catholic moral tradition - can seemingly be constructed that a Catholic healthcare ethics committee might use to justify early induction of labor in some pregnancies involving an anencephalic fetus. Such a revised argument depends upon two central claims; first, that the anencephalic fetus in question is necessarily in the process of dying when early induction of labor occurs, and second, that the fetus is judged to be undergoing extraordinary or disproportionate means of preserving their life as a result of receiving ongoing maternal support of a mother's womb.
View Article and Find Full Text PDFVaginal development during 2nd gestational trimester: translational study in human female fetuses with disorders of the neural tube.
Arch Gynecol Obstet
October 2022
Urogenital Research Unit, State University of Rio de Janeiro, 104/201, Tijuca, Rio de Janeiro, RJ, Brazil.
Purpose: One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the vagina during the human second trimester of pregnancy. Our study compared the biometric parameters of the vagina in human female fetuses with neural tube defects.
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