Tyramine pupillometry was performed in 27 cluster headache patients and in 45 healthy controls. Asymmetry variables, i.e. symptomatic(S)-nonsymptomatic(NS) side diameter difference and the ratios (S/NS, log NS/S or S/S+NS) displayed higher sensitivities than variables which express the function of the symptomatic and the nonsymptomatic side pupil separately. Thirty percent of patients had abnormal S-NS values at maximal pupillary dilatation. The statistical properties of different ratio variables are discussed and it is concluded that the transformed ratio (log(NS/S], anisocoria (S-NS) and the anisocoria index (S/S+NS) may be superior to the conventional S/NS ratio.
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