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The impact of uric acid levels in the pathophysiology and its contribution to the prediction of diagnosis in restless legs syndrome.
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January 2025
Bahcesehir University Medical Faculty, Neurology, Istanbul, Turkey.
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs, worsened in the evening, occurring at rest, and relieved temporarily by movement. Although its pathophysiology remains incompletely understood, oxidative stress has been suggested. Uric acid (UA) is a marker associated with oxidative stress, and its reduced levels pose a risk for certain neurodegenerative diseases.
View Article and Find Full Text PDFInterplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus.
Lupus Sci Med
January 2025
Department of Child Health and Diseases, Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Istanbul, Türkiye
Objective: Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance. However, its pathogenesis is multifactorial and poorly understood. The aim of this study was to evaluate the potential of nuclear factor-kappa B (NF-κB) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) as biomarkers for jSLE.
View Article and Find Full Text PDFEnergy of Functional Brain States Correlates With Cognition in Adolescent-Onset Schizophrenia and Healthy Persons.
Hum Brain Mapp
January 2025
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Adolescent-onset schizophrenia (AOS) is relatively rare, under-studied, and associated with more severe cognitive impairments and poorer outcomes than adult-onset schizophrenia. Neuroimaging has shown altered regional activations (first-order effects) and functional connectivity (second-order effects) in AOS compared to controls. The pairwise maximum entropy model (MEM) integrates first- and second-order factors into a single quantity called energy, which is inversely related to probability of occurrence of brain activity patterns.
View Article and Find Full Text PDFMitochondrial miRNAs and fibromyalgia: new biomarker candidates.
Mol Biol Rep
November 2024
Department of Medical Biology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Article Synopsis
- Fibromyalgia syndrome (FMS) affects 3-10% of people and is challenging to treat due to its complex symptoms; this study focused on the role of mitochondrial miRNAs (mitomiRs) in FMS patients and aimed to profile these miRNAs to find potential targets.
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[Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment].
Cad Saude Publica
September 2024
Universidade Federal de São Paulo, São Paulo, Brasil.
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- Tuberculosis (TB) is a significant global health issue, particularly for children and adolescents in high-prevalence areas, where understanding treatment abandonment factors is limited.
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