AI Article Synopsis
- Modulating ventilatory settings, specifically altering oxygen and ventilation levels, may help treat secondary brain damage in traumatic brain injury (TBI) cases.
- In a study with pigs, those exposed to 100% hyperoxia combined with a 50% decrease in minute volume showed significant improvements in brain oxygenation and reduced lactate levels.
- However, the combination of 100% hyperoxia with a 20% decrease in minute volume resulted in increased intracranial pressure, indicating that careful adjustment of these settings is necessary for effective treatment.
Article Abstract
Modulation in ventilatory settings is one of the approaches and interventions used to treat and prevent secondary brain damage after traumatic brain injury (TBI). Here we investigate the effect of hyperoxia in combination with hypoventilation on brain oxygenation, metabolism and intracranial pressure. Twelve pigs were divided into three groups; group1-100% hyperoxia (n=4), group 2-100% hyperoxia and 20% decrease in minute volume (MV) (n=4) and group 3-100% hyperoxia and 50% decrease in MV (n=4). Neither of the ventilator settings affected the lactate/pyruvate ratio significantly. However, there was a significant decrease of brain lactate (2.6±1.7 to 1.8±1.6mM) and a rapid and marked increase in brain oxygenation (7.9±0.7 to 61.3±17.6mmHg) in group 3. Intracranial pressure (ICP) was not significantly affected in this group, however, the ICP increased significantly in group 2 with 100% hyperoxia plus 20% reduction in minute volume. We conclude that hyperoxia in combination with 50% decrease in MV showed pronounced increase in partial brain oxygen tension (pbrO2) and decrease in brain lactate. The ventilatory modification, used in this study should be considered for further investigation as a possible therapeutic intervention for TBI patients.
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| http://dx.doi.org/10.1016/j.resp.2013.08.010 | DOI Listing |
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