Psychopharmacologic treatment of psychosis in children and adolescents: efficacy and management.

Child Adolesc Psychiatr Clin N Am

Division of Child and Adolescent Psychiatry, Department of Psychiatry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Electronic address:

Published: October 2013

AI Article Synopsis

  • Research shows that antipsychotics can effectively treat children and adolescents with psychosis, supported by multiple randomized controlled trials.
  • Chronic use of second- and third-generation antipsychotics can lead to significant side effects, particularly metabolic syndrome, which clinicians must consider when creating treatment plans.
  • Clozapine is noted for its high efficacy in treating resistant cases in both adults and younger populations, and there are recommendations for managing its side effects.

Article Abstract

The efficacy of antipsychotic use in children and adolescents with psychosis has been shown in an increasing number of randomized controlled trials. Chronic use of second-generation and third-generation antipsychotics has the potential for significant side effects, especially metabolic syndrome. A review of the literature on side effect profiles of antipsychotic medications used in children and adolescents is provided to help clinicians develop treatment plans for their patients. Clozapine has the best efficacy of all antipsychotic medications in adults as well as children and adolescents who are treatment resistant. Guidance is provided for the management of clozapine side effects.

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Source
http://dx.doi.org/10.1016/j.chc.2013.06.002DOI Listing

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