MI paste plus and PreviDent fluoride varnish appear no more effective than normal home care for improving the appearance of white spot lesions.

Article Title And Bibliographic Information: Effectiveness of MI Paste Plus and PreviDent fluoride varnish for treatment of white spot lesions: a randomized controlled trial. Huang GJ, Roloff-Chiang B, Mills BE, Shalchi S, Spiekerman C, Korpak AM, Starrett JL, Greenlee GM, Drangsholt RJ, Matunas JC. Am J Orthod Dentofacial Orthop 2013;143:31-41.

Reviewer: Carmen Llena-Puy

Purpose/question: The authors' aim was to compare the effectiveness of MI Paste Plus and PreviDent fluoride varnish (22,600 ppm of fluoride) with a standard oral hygiene regimen with toothpaste (1100 ppm of fluoride; Colgate Oral Pharmaceuticals)--control group--in improving the appearance of white spot lesions (WSLs) after orthodontic treatment during 8 weeks of follow-up

Source Of Funding: National Institute of Dental and Craniofacial Research

Type Of Study/design: Randomized controlled trial

Level Of Evidence: Level 1: Good-quality, patient-oriented evidence

Strength Of Recommendation Grade: Not applicable.