One of the most important biomaterial characteristics involved in bacterial adhesion on intraocular lenses (IOLs) is hydrophobicity. We calculated the hydrophobicity parameters of IOLs made of 6 different materials (polymethylmethacrylate, PMMA, heparin surface-modified PMMA, HSM-PMMA, silicone, hydrophilic and hydrophobic acrylics and collamer). Values of IOL surface free energy components were determined from contact angle measurements, using the Fowkes, Owens-Wendt and Good-van Oss calculations. Contact angles were higher for silicone and hydrophobic acrylic materials and lower for collamer and hydrophilic acrylic materials. The values of IOL surface free energy components obtained with the 3 different calculations were homogenous. According to the Owens-Wendt calculation, the IOLs could be separated into dispersive implants (hydrophobic acrylic, silicone and PMMA) and polar implants (collamer, hydrophilic acrylic and HSM-PMMA).
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http://dx.doi.org/10.1159/000348738 | DOI Listing |
Prep Biochem Biotechnol
January 2025
Xinjiang University, Xinjiang, China.
This study aimed to optimize the ultrasonic/microwave-assisted extraction (UAME) technique of polysaccharides (EAP-UM) by response surface methodology (RSM). The optimum conditions include: solid-liquid ratio of 1:23 g/mL, ultrasonic power of 252 W, microwave power of 417 W, and extraction time of 11 min. Under these conditions, the yield of polysaccharides reached 7.
View Article and Find Full Text PDFMol Divers
January 2025
Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China.
Influenza is a highly contagious respiratory illness that imposes a significant global burden. Antiviral neuraminidase inhibitors (NAIs) such as oseltamivir (OC) have been proven essential, but the emergence of resistant viral strains necessitates the development of novel therapies. This study explored the potential of natural products as alternative NAIs.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Zhejiang Laboratory, Hangzhou 311100, Zhejiang, China.
Deoxyribonucleic acid (DNA) serves as a repository of genetic information in cells and is a critical molecular target for various antibiotics and anticancer drugs. A profound understanding of small molecule interaction with DNA is crucial for the rational design of DNA-targeted therapies. While the molecular mechanics/Poisson-Boltzmann surface area (MM/PBSA) and molecular mechanics/generalized Born surface area (MM/GBSA) approaches have been well established for predicting protein-ligand binding, their application to DNA-ligand interactions has been less explored.
View Article and Find Full Text PDFAesthet Surg J
January 2025
Department of Dermatology, Erasmus Medical Centre, Rotterdam, the Netherlands and is an Evidence-Based Medicine editor for Aesthetic Surgery Journal.
Background: Effects of upper facial aging can present as static forehead and periorbital rhytids as well as soft tissue volume loss. The latter can prompt in conjunct with bony changes of the calvaria eyebrow and eyelid ptosis. Injection-based treatments can yield positive outcomes but are not free of procedural risks.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
National Key Laboratory of Helicopter Aeromechanics, Nanjing University of Aeronautics & Astronautics, Nanjing, 210016, China.
In this work, the regulation of liquid self-transport is achieved through architectural and thermal coupling, transitioning from free surfaces to open channels. Hierarchical structures inspired by the skin of a Texas horned lizard are designed, with the primary structure of wedged grooves and the secondary structure of capillary crura. This design enables advantages including long-distance self-transport, liquid storage and active reflux management on free surfaces, directional transportation, synthesis and detection of reagents in confined spaces, as well as controllable motion and enhanced heat dissipation in open channels.
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