Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.

Daisuke Yabe Mariyo Rokutan Yoshiyuki Miura Izumi Komoto Ryota Usui Hitoshi Kuwata Koin Watanabe Takanori Hyo Takeshi Kurose Terumi Nagamatsu Shinobu Shimizu Jun Kawai Masayuki Imamura Yutaka Seino

Diabetes Res Clin Pract

Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan; Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2-1-7 Fukushima-ku, Osaka 553-0003, Japan. Electronic address:

Published: October 2013

We examined GLP-1 secretion from the pancreas of a patient with glucagonoma and pancreatic resection by measuring GLP-1 after meal ingestion or selective arterial calcium injection, and immunohistochemical analysis. Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans.

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http://dx.doi.org/10.1016/j.diabres.2013.08.005	DOI Listing

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