Background: There are documented molecular homologies between mites from the same group, but intergroup characteristics are not. Although mites share the same taxonomic order, there are species antigenically distinct. At the present we dont know clearly the differences in cutaneous reactivity among several house dust mites species.
Objetive: to estimate the correlation of skin reactivity to Dermatophagoides pteronyssinus and Dermatophagoides farinae antigens with that of Blomia tropicalis in patients with allergic rhinitis and asthma.
Methods: a cross sectional, observational, prolective and interpretive study was performed in patients of both genders, aged 2 to 58 with allergic rhinitis and asthma. All patients underwent skin prick tests with allergenic extracts.
Results: One hundred and ten patients were included, with an age average of 24.1 years; 50% were males. There were positive skin tests with mites in 59% of the patients, 24.5% for Blomia t; 10% for D. pteronyssinus plus Blomia t. and 7.29% for D. farinae plus Blomia t. The correlation of the skin reactivity between Dermatophagoides pteronyssinus and Blomia tropicalis (r= 0.36) and between Dermatophagoides farinae and Blomia tropicalis (r= 0.27), was not significant in both cases.
Conclusions: We found that most patients with allergic rhinitis and asthma showed positive skin tests with the mite extracts tested. There is a weak correlation between both species of Dermatophagoides and Blomia tropicalis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Clinical Trial With a Depigmented, Polymerized Mite Mixture Extract at Maximum Concentrations.
Immun Inflamm Dis
December 2024
Medical Affairs and Clinical Department, LETI Pharma S.L.U., Madrid, Spain.
Background: Efficacy of allergen immunotherapy is dose-dependent; however, high doses of allergen may imply a greater risk of adverse reactions.
Objective: To assess the safety and tolerability of subcutaneous immunotherapy (SCIT) with mixtures of mite allergen extracts, Dermatophagoides pteronyssinus/Blomia tropicalis (Dpt/Bt) and Dermatophagoides pteronyssinus/Lepidoglyphus destructor (Dpt/Ld) at maximum concentrations, in adult patients with allergic rhinitis or rhinoconjunctivitis, and controlled allergic asthma due to a clinically relevant sensitisation to these mites.
Methods: An open-label, noncontrolled, nonrandomised, phase IIb clinical trial was carried out in three hospitals in Spain between September 2014 and May 2018.
Blomia tropicalis: A 50-Year History.
J Allergy Clin Immunol Pract
November 2024
Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla.
Article Synopsis
- * The discovery of 26 B. tropicalis allergens, some cross-reactive with other mite species, complicates diagnosis and treatment options for allergies, though advancements in component-resolved diagnostics aid in this process.
- * Immunotherapy using B. tropicalis extracts is effectively implemented in various countries, but there is a challenge with the limited availability of standardized extracts, despite significant research contributions over the past five decades on allergen characterization and potential impacts of climate change.
Nasal allergen challenge with Blomia tropicalis in children and adolescents.
Allergol Immunopathol (Madr)
November 2024
Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
Background: Local allergic rhinitis (LAR) is a well-defined phenotype in adults, but still there is little data available on children. This scarcity of data can be partly attributed to the lack of standardized protocols for Nasal Allergen Challenges (NAC) in this demographic.
Methods: 20 controls (control group) and 24 patients (rhinitis group) with allergic rhinitis diagnosis sensitized to Blomia tropicalis (Bt) underwent the NAC with Bt.
Agreement of Peru-Based Allergy Tests for Respiratory Allergens in Allergic Rhinitis Patients.
J Immunol Res
November 2024
SANNA el Golf Clinic, Lima, Peru.
Article Synopsis
- The study evaluated the agreement between three allergy testing methods—Peruvian Immunoblot, SPT (skin prick tests), and ALEX-2—in patients with allergic rhinitis in Arequipa, Peru.
- 35 patients participated, with findings indicating varying sensitization rates for allergens not covered by the Immunoblot panel.
- The results revealed stronger concordance between ALEX-2 and SPT compared to the agreement between Immunoblot and SPT.
NMR residual dipolar couplings investigation in the topology of house dust mite Group V allergens.
J Struct Biol
December 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address:
Blo t 5 is an important major allergen protein from Blomia tropicalis mites, which are prevalent in tropical and subtropical regions, including Taiwan. It is a coiled-coil triple helical bundle, but there currently is ambiguity around its structural fold and packing of the three helices. We have relied on NMR residual dipolar coupling data collected from four different alignment media to confirm that Blo t 5 has left-handed helical topology and further used that data to refine its solution structure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!