The o-palladated, chloro-bridged dimers [Pd{2-phenylpyridine(-H)}-μ-Cl]2 and [Pd{N,N-dimethylbenzylamine(-H)}-μ-Cl]2 react with cyanuric acid in the presence of base to afford closed, chiral cage-molecules in which 12 organo-Pd(II) centers, located in pairs at the vertices of an octahedron, are linked by four tetrahedrally arranged cyanurato(3-) ligands. Incomplete (Pd10) cages, having structures derived from the corresponding Pd12 cages by replacing one pair of organopalladium centers with two protons, have also been isolated. Reaction of [Pd{2-phenylpyridine(-H)}-μ-Cl]2 with trithiocyanuric acid gives an entirely different and more open type of cage-complex, comprising only nine organopalladium centers and three thiocyanurato(3-) ligands: cage-closure in this latter system appears to be inhibited by steric crowding of the thiocarbonyl groups.
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http://dx.doi.org/10.1021/ic401253q | DOI Listing |
J Am Chem Soc
September 2024
Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China.
The synthesis of complex polysubstituted aromatic molecules from simple precursors is a central goal in organic chemistry. In this study, we developed an approach for the -alkylation of iodoarenes utilizing a dual ligand catalytic system. By combining Pd/olefin ligand cooperative catalysis with bulky trialkylphosphine ligand-promoted C(sp)-I reductive elimination, we have established an -alkylative Catellani-type reaction with the aryl-iodine bond reconstruction as the final step, which opens new synthetic opportunities within the Catellani-type reactions.
View Article and Find Full Text PDFInorg Chem
June 2023
Instituto de Síntesis Química y Catálisis Homogénea, ISQCH (CSIC-Universidad de Zaragoza), Pedro Cerbuna 12, 50009 Zaragoza, Spain.
Weakly fluorescent ()-4-arylidene-5-(4)-oxazolones (), Φ < 0.1%, containing a variety of conjugated aromatic fragments and/or charged arylidene moieties, have been orthopalladated by reaction with Pd(OAc). The resulting dinuclear complexes () have the oxazolone ligands bonded as a C^N-chelate, restricting intramolecular motions involving the oxazolone.
View Article and Find Full Text PDFJ Org Chem
July 2023
School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China.
Herein, a reaction in which the benzyl C-H bonds of alkylarenes are directly esterified by carboxylic acids to produce benzyl esters in high yields is reported. This reaction is catalyzed by Pd nanoparticles (NPs) on -doped carbon (CN) composites based on a carbonizing Al-MIL-101(NH) material, and no oxidants or hydrogen acceptors are required. Use of -alkylbenzoic acids as substrates leads to phthalides, whereas with carboxylic acids and alkylarenes as the feedstock, the reaction produces the benzyl esters.
View Article and Find Full Text PDFPharmaceutics
April 2023
Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.
Combined treatments employing lower concentrations of different drugs are used and studied to develop new and more effective anticancer therapeutic approaches. The combination therapy could be of great interest in the controlling of cancer. Regarding this, our research group has recently shown that peptide nucleic acids (PNAs) that target miR-221 are very effective and functional in inducing apoptosis of many tumor cells, including glioblastoma and colon cancer cells.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2023
Center for Supramolecular Chemistry and Catalysis, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, P. R. China.
A non-aromatic expanded carbaporphyrinoid, incorporating two built-in 2,7-pyrenylene moieties was synthesized. The intrinsically labile structure was demonstrated by proton-triggered conformational changes between the figure-of-eight and quasi-Möbius conformers. Upon treatment with Pd(OAc) , the reaction produces two bis-Pd complexes with distinct coordination modes.
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