In nude mice grieofulvin given by intraperitoneal injections produces a severe porphyric state within 1 week. Compared with peroral administration of griseofulvin to produce experimental porphyria, this model is much more efficient and can be more easily controlled.
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A metabolomic perspective of griseofulvin-induced liver injury in mice.
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Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:
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