AI Article Synopsis
- Six compounds were extracted from the stems of Clausena lansium using silica gel column chromatography, and their structures were determined through physical and spectroscopic methods.
- Two of these compounds, 8-geranyloxypsolaren and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde, were identified for the first time in this plant.
- Compounds 4 to 6 showed strong cytotoxic effects against certain cancer cell lines, particularly H1299 and SMMC-7721, with IC₅₀ values ranging from 6.19 to 26.84 μg/mL.
Article Abstract
Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4-6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC₅₀ values of 6.19 to 26.84 μg/mL.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270150 | PMC |
| http://dx.doi.org/10.3390/molecules180910768 | DOI Listing |
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