The objective of the present study was to improve the methods for mechanical nasal bleeding (NB) control. To this effect, the authors undertook a prospective comparative study of the effectiveness and safety of two mechanical techniques for nasal tamponade in the patients suffering from nasal bleeding. A total of 48 patients with NB and concomitant arterial hypertension were recruited for the study. In 20 of them, nasal bleeding was arrested with the help of an Epistop-3 three-balloon silicone catheter; in the remaining 28 patients, the gauze packs were used for the purpose. The conditions of the nasal cavity were assessed on the day when the pack was removed and during the next three days by the endoscopic technique and calculation of the mucociliary transport (MCT) time. The subjective assessment of the quality of life by the patients was taken into consideration. The study revealed no relapses of NB in the first group while hyperemia, oedema of nasal cavity mucosa, fibrinous pellicles and crusts were less manifested than in the control patients; moreover, the function of ciliated epithelium and the patients' quality of life were less affected (p<0.05). In the control group, recurrent NB episodes occurred in 42.9% of the patients. It is concluded that the application of the Epistop-3 catheter reduces duration of the rehabilitation period in the patients with NB. The device is fairly well tolerated by the patients; it is less injurious to the intranasal mucous membrane than the gauze pack.
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Laryngoscope
December 2024
Department of Otolaryngology-Head and Neck Surgery, Zain Hospital, Ministry of Health, Kuwait City, Kuwait.
Objective: To conduct a systematic review and network meta-analysis to evaluate the safety and efficacy of intrapolyp steroid injection compared with oral steroids, nasal steroid wash, nasal steroid spray, and a control group in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Data Sources: PubMed, Scopus, Web of Science, Embase, and CENTRAL.
Review Methods: Both randomized and non-randomized clinical trials were included.
Front Med (Lausanne)
December 2024
Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a biphasic epithelial tumor associated with HPV infection. This rare tumor primarily affects the nasal cavity and paranasal sinuses, with only two cases reported outside these locations to date-one in the breast and one in the vulva. This report presents a case of a tumor resembling an HMSC arising in the cervix.
View Article and Find Full Text PDFSinonasal inverted papilloma (SNIP) is less malignant and usually occur in the maxillary sinus. However, cases invading the pterygopalatine fossa are extremely rare. In this article, we describe a rare case of a man in his early 60s who presented with left nasal congestion, headache, epistaxis, and facial numbness.
View Article and Find Full Text PDFSemin Thromb Hemost
December 2024
Gastroenterology Department, HHT European Reference Center, ASST Ospedale Maggiore Crema, Crema, Italy.
Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder with highly variable penetrance, affecting up to 1 in 5,000 individuals. It is characterized by the presence of abnormal blood vessels that can lead to excessive bleeding-most frequently recurrent nosebleeds (epistaxis), skin and mucosal telangiectasias (small, dilated blood vessels), as well as arteriovenous malformations (AVMs) that can form in various organs, particularly the lungs, liver, and brain. HHT is caused by loss-of-function mutations in the BMP9-10/ENG/ALK1/SMAD4 signaling pathway, an important mediator of vascular quiescence.
View Article and Find Full Text PDFIsr Med Assoc J
December 2024
Parasitology Unit, Department of Microbiology and Molecular Genetics, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
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