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Intracranial angioleiomyoma mimicking meningioma: an uncommon tumor with favorable outcome and frequent GJA4 mutation.
Neurosurg Rev
November 2024
Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Article Synopsis
- Intracranial angioleiomyoma (IALM) is a rare brain tumor that resembles meningioma, accounting for about 10% of angioleiomyomas and predominantly affecting males, particularly in the orbital and cavernous sinus areas.
- *The study analyzed 40 patients who underwent tumor resection and found that symptoms like vision impairment and diplopia were common, with a significant portion misdiagnosed as meningioma prior to surgery.
- *Postoperative results indicated a clinically benign nature of IALM with no recurrence, and GJA4 mutations were noted in 42.5% of cases, correlating with progesterone receptor expression and suggesting a possible molecular link.
Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.
Head Neck Pathol
October 2024
Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Article Synopsis
- Mesenchymal neoplasms in the nasal cavity, such as angioleiomyoma (AL) and angiomyolipoma (AML), are rare tumors that involve vascular, smooth muscle, and adipocytic components, with unclear classifications as hamartomas or true neoplasms due to limited genetic research.
- A multi-institutional retrospective study collected data on 15 nasal cavity lesions, primarily affecting older males with obstructive symptoms, and analyzed tissue samples for genetic features.
- The study discovered that most cases had a high proportion of smooth muscle, with some showing additional components like blood vessels and fatty tissue, while all lesions were positive for smooth muscle markers, indicating their muscular origin.
Clinical characteristics and treatment outcomes of angioleiomyoma of the female genital tract: a retrospective cohort study.
BMC Womens Health
August 2024
Department of Gynecology, The Third Xiangya Hospital of Central South University, NO. 138 Tongzipo, Yuelu District, Changsha, 410013, Hunan, China.
Background: Angioleiomyoma, a benign tumour composed of smooth muscle cells and thick-walled vessels, is expected to be very rare in the female genital tract. This study aimed to describe the clinicopathological features and treatment outcomes of angioleiomyoma in the female genital tract.
Methods: We retrospectively reviewed 89 women with angioleiomyoma in the genital tract who were treated at Third Xiangya Hospital of Central South University between July 2008 and October 2023.
Angioleiomyoma of the Foot: Clinical and Functional Outcomes of Surgical Treatment in a Case Series.
J Am Podiatr Med Assoc
July 2024
*Department of Orthopedics and Trauma Surgery, University of Pisa, Pisa, Italy.
Background: Angioleiomyoma is a benign soft-tissue tumor that arises from the smooth muscle cells in the tunica media of the blood vessels. Although the most common location for these neoplasms is the uterine wall, they can also originate from lower limbs. Altogether, these neoplasms account for 0.
View Article and Find Full Text PDFCT and MRI Findings of Renal Angiomyolipoma With Lung Metastasis: A Case Report and Literature Review.
Clin Respir J
July 2024
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Renal angiomyolipoma has two histological variants: classical and epithelioid. Epithelioid angiomyolipoma is considered as a potential malignant tumor, often leading to recurrence and metastasis, with rapid progression in most of the cases. The lung is one of the most commonly reported sites of metastasis, and pulmonary metastasis of renal angiomyolipoma is usually diagnostic by computed tomography (CT) scans.
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