Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan.

Jingyu Zhang Wael M Abdel-Mageed Miaomiao Liu Pei Huang Wenni He Li Li Fuhang Song Huanqin Dai Xueting Liu Jingyu Liang Lixin Zhang

Org Lett

Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology Chinese Academy of Sciences , Beijing, 100080, China, Department of Natural Medicinal Chemistry, China Pharmaceutical University , Nanjing 210009, China, Department of Pharmacognosy, College of Pharmacy, King Saud University , Riyadh 11451, Kingdom of Saudi Arabia, Department of Pharmacognosy, Faculty of Pharmacy, Assiut University , Assiut 71526, Egypt, Department of Medicinal Chemistry, Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China, and University of Chinese Academy of Sciences, Beijing, 100049, China.

Published: September 2013

Serial antibacterial furanoditerpenes caesanines A-D (1-4), possessing a cassane-type diterpenoid skeleton with an unusual N bridge between C-19/C-20, were identified from a Chinese herb Caesalpinia sappan Linn. In addition, caesanine D (4) showed the first class of dicassane diterpenoid ethers. Their structures were determined by different spectroscopic methods and ECD calculation. Caesanines A and B exhibited strong activities against MRSA suggesting a promising entry point for the development of anti-infective drugs.

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http://dx.doi.org/10.1021/ol402058z	DOI Listing

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