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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, Los Angeles, CA, USA.
Background: Dementia exhibits abnormal network activity, including altered gamma frequency (30-100 Hz) in Alzheimer's disease (AD). A non-pharmacological, non-invasive approach to AD treatment involves stimulating sensory inputs using gamma band, with 40 Hz as the most effective in eliciting a robust EEG response. Light and sound stimulation at 40 Hz reduces AD pathology in mouse models and improves cognition in humans with AD.
View Article and Find Full Text PDFAchieving Superior Thermoelectric Performance in Methoxy-Functionalized MXenes: The Role of Organic Functionalization.
ACS Appl Mater Interfaces
January 2025
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, P. R. China.
Thermoelectric technology enables the direct and reversible conversion of heat into electrical energy without air pollution. Herein, the stability, electronic structure, and thermoelectric properties of methoxy-functionalized MC(OMe) (M = Sc, Ti, V, Cr, Y, Zr, Nb, Mo, Hf, Ta, and W) were systematically investigated using first-principles calculations and semiclassical Boltzmann transport theory. All MXenes, except those with M = Cr, Mo, and W, can be synthesized by substituting Cl- and Br-functionalized MXenes with deprotonated methanol, with stability governed by the M-O bond strength.
View Article and Find Full Text PDFFuture clinical trials targeting Alzheimer's disease (AD) on new disease modifying drugs necessitate a paradigm shift towards early identification of individuals at risk. Emerging evidence indicates that subtle alterations in language and speech characteristics may manifest concurrently with the progression of neurodegenerative disorders like AD. These changes manifest as discernible variations, assessable through semantic nuances, word choices, sentiment, grammar usage (linguistic features), and phonetic/acoustic traits (paralinguistic features).
View Article and Find Full Text PDFA sound approach for ova denudation.
F S Sci
December 2024
The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:
Article Synopsis
- Developed a non-contact method using acousto-hydrodynamic tweezers (AHT) for denuding cumulus-oocyte complexes (COCs), showing higher efficiency compared to traditional manual methods.
- Tested on mice, the method demonstrated no damage to oocytes and reduced denudation time by 46% while maintaining embryo development rates.
- Findings suggest that using acoustic waves can significantly improve the denudation process for intracytoplasmic sperm injection (ICSI), potentially enhancing fertility treatment procedures.
Influence of cell shape on sonoporation efficiency in microbubble-facilitated delivery using micropatterned cell arrays.
Sci Rep
December 2024
State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin, 300072, China.
Microbubble-facilitated sonoporation is a rapid, versatile, and non-viral intracellular delivery technique with potential for clinical and ex vivo cell engineering applications. We developed a micropatterning-based approach to investigate the impact of cell shape on sonoporation efficacy. Cationic microbubbles were employed to enhance sonoporation by binding to the cell membrane electrostatically.
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